Review Article
Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
Figure 5
Mechanisms of 5-HT2A receptor antagonist contributing to DM-induced cardiovascular complications. Sarpogrelate, a 5-HT2AR antagonist, has been shown to attenuate diabetes-induced cardiovascular complications, which decrease the blood glucose level, inhibit the release of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), and reduce 5-HT-induced contraction in aortas through the PI3K and Rho kinase pathway.