Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease

<div>Illustration to show the mechanism of 5-HT<sub>2A</sub>R in mesangial cells. 5-HT has been shown to enhance the production of type IV collagen by human mesangial cells, and its production is mediated by the activation of protein kinase C and a subsequent increase in active TGF-<i>β</i>. Stimulation of 5-HT2ARs by 5-HT induces the expression of TGF-<i>β</i> through extracellular signal-regulated kinases.</div>

Journal of Diabetes Research

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Figure 6

Figure 6: Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease 