Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C
Table 2
Characteristics of the participates.
Parameters
LADA patients ()
Control subjects ()
LADA patients
Complication-free ()
With complication ()
Gender (male%)
46.2%
46.2%
50.0%
42.9%
Age (years)
43 ± 9
39 ± 9
37 ± 7
48 ± 10
BMI (kg/m2)
23.9 ± 3.6
23.6 ± 3.9
23.7 ± 4.1
24.0 ± 4.2
Diabetes duration (years)
9 ± 7
0
5 ± 5
12 ± 8
HbA1c (%)
9.6 ± 2.6
5.2 ± 0.3
8.0 ± 2.3
12.1 ± 2.8
FCP (nmol/l)
0.49 ± 0.27
—
0.62 ± 0.32
0.37 ± 0.28
Low FCP
8/26 (30.8%)
—
2/12 (16.7%)
6/14 (42.9%)
High titer GADA
9/26 (34.6%)
—
4/12 (33.3%)
5/14 (35.7%)
Low titer GADA
17/26 (65.4%)
—
8/12 (66.7%)
9/14 (64.3%)
Total cholesterol (mmol/l)
4.2 ± 1.0
4.3 ± 1.0
4.1 ± 0.9
4.3 ± 1.1
Triglyceride (mmol/l)
1.8 ± 1.1
1.9 ± 1.2
1.7 ± 0.9
1.9 ± 1.4
HDL cholesterol (mmol/l)
1.3 ± 0.3
1.2 ± 0.3
1.3 ± 0.3
1.3 ± 0.2
LDL cholesterol (mmol/l)
2.5 ± 0.7
2.4 ± 0.8
2.4 ± 0.7
2.5 ± 0.8
Serum creatinine (umol/l)
102 ± 18.9
80 ± 17.2
96 ± 12.8
108 ± 16.7
, number of subjects; BMI, body mass index; HbA1c, glycated hemoglobin; FCP, fasting C-peptide; HDL, high-density lipoprotein; LDL, low-density lipoprotein; GADA, glutamic acid decarboxylase antibody. , , LADA patients compared with controls. , LADA patients with complications compared with LADA patients without complications.
