Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C

Table 3

Correlation analysis of global histone H3 lysine 4 and H3 lysine 9 methylation in CD4⁺ T lymphocytes from LADA patients.

	H3 lysine 4 methylation ()		H3 lysine 9 methylation ()
	Age	0.456	0.367	0.376	0.235
BMI	0.075	0.789	0.127	0.665
HbA1c	−0.347	0.129	−0.546	0.098
FCP	0.163	0.102	0.174	0.526
Duration of Diabetes	0.223	0.424	0.114	0.197
Total cholesterol	0.015	0.680	−0.186	0.214
Triglyceride	0.074	0.823	−0.235	0.556
HDL cholesterol	0.128	0.276	−0.469	0.109
LDL cholesterol	0.217	0.289	−0.159	0.245
Serum creatinine	−0.136	0.212	−0.267	0.334
GADA titer	−0.336	0.183	−0.824	0.021

H3 lysine 4 methylation and H3 lysine 9 methylation in LADA patients’ CD4⁺ T lymphocytes were not correlated with age, BMI, HbA1c, FCP, duration of diabetes, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, and serum creatinine. H3 lysine 9 methylation was associated with GADA titer.
, number of subjects; BMI, body mass index; HbA1c, glycated hemoglobin; FCP, fasting C-peptide; HDL, high-density lipoprotein; LDL, low-density lipoprotein; GADA, glutamic acid decarboxylase antibody.