Review Article

The Effectiveness of Lifestyle Adaptation for the Prevention of Prediabetes in Adults: A Systematic Review

Table 5

Summary of secondary outcomes.

#Study BMI change (kg/m2)Weight change (kg)Physical exercise capacity

(1)Knowler et al. [17]Not primary or secondary outcome of the study50% of the intervention group achieved ≥7% weight loss by 24 weeks. At the end of the study this was 38%
Average weight loss was 5.6 kg in intervention and 0.1 kg in control
Activity levels of 150 minutes a week met by 74% of intervention group at 24 weeks. This reduced to 58% by the end of the study

(2)Kosaka et al. [18]Not primary or secondary outcome of the studyIn intervention group body weight decreased by 2.5 kg after 1 year and then increased thereafter but remained 2.18 kg lower than baseline at 4 years.
Control group’s weight decreased by 0.39 kg by end of 4 years
Not primary or secondary outcome

(3)Lindström et al. [19]BMI at baseline for intervention = 31.4 ± 4.5, at 1 year = −1.6 ± 1.8, and at 3 years = −1.3 ± 1.9.
BMI at baseline for control = 31.1 ± 4.5, at 1 year = −0.4 ± 1.3, and at 3 years = −0.3 ± 2.0
Target to lose ≥ 5% weight achieved by year one: 46% in intervention and 14% in control.
Weight for intervention at baseline = 86.7 ± 14.0, at 1 year = −4.5 ± 5.0, and at 3 years = −3.5 ± 5.1. Weight for control at baseline = 85.5 ± 14.4, at 1 year = −1.0 ± 3.7, and at 3 years = −0.9 ± 5.4
Moderate to vigorous leisure time activity increased in the intervention group compared to the control group. Intervention group at baseline (min/week): mean of 16 minutes and increased to mean of 50 minutes. Control group at baseline (min/week): mean of 21 minutes and increased to mean of 23 minutes.

(4)Moore et al. [20]BMI at baseline for intervention = 29.66 ± 5.33 and at 6 months = 28.72 ± 5.00.
BMI at baseline for control = 29.79 ± 4.94 and at 6 months = 29.50 ± 5.24
Weight for intervention at baseline = 80.7 kg ± 16.01 and at 6 months = 78.11 ± 14.98.
Weight for control group at baseline = 82.02 ± 16.27 and at 6 months = 81.20 ± 17.39
Not primary or secondary outcome

(5)Penn et al. [21]Not primary or secondary outcome of the studyChange in mean weight at 1 year for intervention and control groups was −2.3 kg and +0.01 kg, respectivelyThere were no significant differences in sustained physical activity levels

(6)Ramachandran et al. [22]Not primary or secondary outcome of the studyNo significant difference in weight seen with intervention group and significant increase in weight for control group (figure not provided estimated at 0.7 kg increase from graph provided)Physical activity adherence showed an improvement of 41.7% to 58.8% in intervention group from baseline to the end of study

(7)Roumen et al. [23]Mean BMI for intervention from baseline = 29.6 ± 3.8, 1 year = −0.94 ± 1.25, 2 years = −0.61 ± 1.49, and 3 years = −0.36 ± 1.47.
Mean BMI for control from baseline = 29.2 ± 3.3, 1 year = −0.20 ± 1.39, 2 years = −0.02 ± 1.17,
and 3 years = +0.08 ± 1.80
Mean weight (kg) change for intervention from baseline of 87.5 ± 13.7, 1 year = −2.77 ± 3.69, 2 years = −1.76 ± 4.34, and 3 years = −1.08 ± 4.30.
Mean weight change for control from baseline of 83.0 ± 11.7, 1 year = −0.62 ± 3.92, 2 years = −0.11 ± 3.26,
and 3 years = +0.16 ± 4.91
In the intervention group, the number of days where at least 30 minutes of physical activity was achieved increased by 0.89 ± 2.75 days from baseline, while in the control group the number of days decreased by −0.55 ± 3.31.
VO2 (l/min) max at baseline for intervention = 2.22 ± 0.61; this changed at 1 year = +0.13 ± 0.25,
2 years = 0.10 ± 0.25,
and 3 years = 0.05 ± 0.35.
VO2 max for control at baseline = 2.13 ± 0.55; this changed at 1 year = +0.02 ± 0.21,
2 years = −0.05 ± 0.23, and 3 years = −0.06 ± 0.21

(8)Saito et al. [24]Not primary or secondary outcome of the studyAchieving weight loss of 5% or more at 36 months = 32% for intervention and 18% for control.
Mean weight reduction at 36 months = 2.5 kg for intervention and 1.1 kg for control
Not primary or secondary outcome

(9)Xu et al. [25]BMI for intervention at baseline = 26.80 ± 3.13 and at 1 year = −0.66 ± 0.13. BMI for control at baseline = 25.72 ± 3.83 and at 1 year = −0.22 ± 0.15Weight loss for intervention at baseline was 68.24 ± 9.73 and changed at 1 year to −1.75 ± 0.35.
Weight loss for control at baseline was 69.69 ± 10.36 and changed at 1 year to −0.55 ± 0.40
Not primary or secondary outcome

BMI: body mass index (kg/m2); VO2: oxygen volume (ltr/min).