Research Article

db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet

Figure 2

Increased fat mass occurs in both diet-induced and genetically driven forms of obesity. Fat mass (a) and % fat mass (e) in male C57BL/6J mice fed either control or Western diet for 20 weeks. Total fat mass gain (c) at the end of the 20-week feeding period. Fat mass (b) and % fat mass (f) in male db/+ and db/db mice between 6 and 14 weeks of age. Total fat mass gain by 14 weeks of age (d). For fat mass measurements, y-axes are set to the same scale for comparison between study groups. per group; means ± SEM; versus control; versus control by repeated measures ANOVA. CD: control diet; WD: Western diet.