Research Article

db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet

Figure 5

Increased expression of inflammatory markers is evident in epididymal adipose tissue from both genetic and diet-induced obesity. Relative mRNA abundance of the inflammatory genes Il1a (a, b), Nod1 (c, d), Ccl2 (e, f), and Cd68 (g, h) in epididymal adipose tissue from either C57BL/6J mice fed either control or Western diet for 4, 12, and 20 weeks (a, c, e, g) or 8- and 14-week-old db/+ and db/db mice (b, d, f, h). per group. Data are normalized to the reference gene Ppia and are represented as means ± SEM. ; ; ; # by one-way ANOVA with Tukey’s post hoc analysis. (a), (e), and (g) values versus respective 4-week dietary group unless denoted by bar. CD: control diet; WD: Western diet; wo: weeks old.