Research Article

db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet

Figure 8

Circulating insulin levels are elevated in both mouse models of obesity, but glucagon is increased only in the db/db mice. Serum insulin (a, b) and glucagon (g, h) in C57BL/6J mice fed either control or Western diet for the indicated number of weeks (a, g) or 14-week-old db/+ and db/db mice (b, h). Serum insulin correlated to body mass or fat mass in C57BL/6J mice fed Western diet for 20 weeks (c and e, resp.) and in 14-week-old db/db mice (d and f, resp.) by Spearman’s correlation. per group; means ± SEM; ; ; . CD: control diet; WD: Western diet.