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Journal of Diabetes Research
Volume 2017 (2017), Article ID 8927473, 19 pages
https://doi.org/10.1155/2017/8927473
Review Article

Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros

First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens Medical School, Laiko General Hospital, Athens, Greece

Correspondence should be addressed to Konstantinos Makrilakis; rg.aou.dem@alirkamk

Received 26 June 2017; Revised 17 October 2017; Accepted 5 November 2017; Published 14 December 2017

Academic Editor: Kim Connelly

Copyright © 2017 Konstantinos Makrilakis and Stavros Liatis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. International Diabetes Federation (IDF), “IDF Diabetes Atlas,” 7th edition edition, 2015, https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/13-diabetes-atlas-seventh-edition.html. View at Google Scholar
  2. T. Seuring, O. Archangelidi, and M. Suhrcke, “The economic costs of type 2 diabetes: a global systematic review,” PharmacoEconomics, vol. 33, no. 8, pp. 811–831, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. UKPDS, “Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group,” Lancet, vol. 352, no. 9131, pp. 837–853, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. R. R. Holman, S. K. Paul, M. A. Bethel, D. R. Matthews, and H. A. W. Neil, “10-year follow-up of intensive glucose control in type 2 diabetes,” The New England Journal of Medicine, vol. 359, no. 15, pp. 1577–1589, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Gu, C. C. Cowie, and M. I. Harris, “Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993,” Diabetes Care, vol. 21, no. 7, pp. 1138–1145, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. O. H. Franco, E. W. Steyerberg, F. B. Hu, J. Mackenbach, and W. Nusselder, “Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease,” Archives of Internal Medicine, vol. 167, no. 11, pp. 1145–1151, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Rao Kondapally Seshasai, S. Kaptoge, A. Thompson et al., “Diabetes mellitus, fasting glucose, and risk of cause-specific death,” The New England Journal of Medicine, vol. 364, no. 9, pp. 829–841, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. M. I. Uusitupa, L. K. Niskanen, O. Siitonen, E. Voutilainen, and K. Pyörälä, “Ten-year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in type 2 (non-insulin-dependent) diabetic and non-diabetic subjects,” Diabetologia, vol. 36, no. 11, pp. 1175–1184, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. B. M. Leon and T. M. Maddox, “Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research,” World Journal of Diabetes, vol. 6, no. 13, pp. 1246–1258, 2015. View at Publisher · View at Google Scholar
  10. A. S. Matheus, L. R. Tannus, R. A. Cobas, C. C. Palma, C. A. Negrato, and M. B. Gomes, “Impact of diabetes on cardiovascular disease: an update,” International Journal of Hypertension, vol. 2013, Article ID 653789, 15 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Nitenberg, P. Valensi, R. Sachs, M. Dali, E. Aptecar, and J. R. Attali, “Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function,” Diabetes, vol. 42, no. 7, pp. 1017–1025, 1993. View at Publisher · View at Google Scholar
  12. A. Nitenberg, F. Paycha, S. Ledoux, R. Sachs, J. R. Attali, and P. Valensi, “Coronary artery responses to physiological stimuli are improved by deferoxamine but not by L-arginine in non-insulin-dependent diabetic patients with angiographically normal coronary arteries and no other risk factors,” Circulation, vol. 97, no. 8, pp. 736–743, 1998. View at Publisher · View at Google Scholar
  13. J. P. J. Halcox, W. H. Schenke, G. Zalos et al., “Prognostic value of coronary vascular endothelial dysfunction,” Circulation, vol. 106, no. 6, pp. 653–658, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Shaw and T. Anderson, “Coronary endothelial dysfunction in non-obstructive coronary artery disease: risk, pathogenesis, diagnosis and therapy,” Vascular Medicine, vol. 21, no. 2, pp. 146–155, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Pasupathy, T. Air, R. P. Dreyer, R. Tavella, and J. F. Beltrame, “Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries,” Circulation, vol. 131, no. 10, pp. 861–870, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Najib, S. Boateng, S. Sangodkar et al., “Incidence and characteristics of patients presenting with acute myocardial infarction and non-obstructive coronary artery disease,” Catheterization and Cardiovascular Interventions, vol. 86, Supplement S1, pp. S23–S27, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. G. O. von Mering, C. B. Arant, T. R. Wessel et al., “Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE),” Circulation, vol. 109, no. 6, pp. 722–725, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. A. Beckman, M. A. Creager, and P. Libby, “Diabetes and atherosclerosis: epidemiology, pathophysiology, and management,” JAMA, vol. 287, no. 19, pp. 2570–2581, 2002. View at Publisher · View at Google Scholar
  19. J. Stamler, O. Vaccaro, J. D. Neaton, and D. Wentworth, “Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial,” Diabetes Care, vol. 16, no. 2, pp. 434–444, 1993. View at Publisher · View at Google Scholar
  20. A. Melidonis, V. Dimopoulos, E. Lempidakis et al., “Angiographic study of coronary artery disease in diabetic patients in comparison with nondiabetic patients,” Angiology, vol. 50, no. 12, pp. 997–1006, 1999. View at Publisher · View at Google Scholar
  21. S. Schiekofer, B. Balletshofer, M. Andrassy, A. Bierhaus, and P. P. Nawroth, “Endothelial dysfunction in diabetes mellitus,” Seminars in Thrombosis and Hemostasis, vol. 26, no. 5, pp. 503–512, 2000. View at Google Scholar
  22. C. B. Granger, R. M. Califf, S. Young et al., “Outcome of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic agents. The Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group,” Journal of the American College of Cardiology, vol. 21, no. 4, pp. 920–925, 1993. View at Publisher · View at Google Scholar · View at Scopus
  23. P. R. Moreno, A. M. Murcia, I. F. Palacios et al., “Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus,” Circulation, vol. 102, no. 18, pp. 2180–2184, 2000. View at Publisher · View at Google Scholar
  24. G. L. Booth, M. K. Kapral, K. Fung, and J. V. Tu, “Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study,” The Lancet, vol. 368, no. 9529, pp. 29–36, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Huxley, F. Barzi, and M. Woodward, “Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies,” BMJ, vol. 332, no. 7533, pp. 73–78, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. A. De Lorenzo, R. S. L. Lima, A. G. Siqueira-Filho, and M. R. Pantoja, “Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with diabetes mellitus and no known coronary artery disease,” The American Journal of Cardiology, vol. 90, no. 8, pp. 827–832, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. T. D. Miller, N. Rajagopalan, D. O. Hodge, R. L. Frye, and R. J. Gibbons, “Yield of stress single-photon emission computed tomography in asymptomatic patients with diabetes,” American Heart Journal, vol. 147, no. 5, pp. 890–896, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Langer, M. R. Freeman, R. G. Josse, and P. W. Armstrong, “Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia,” Journal of the American College of Cardiology, vol. 25, no. 3, pp. 610–618, 1995. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Scognamiglio, C. Negut, A. Ramondo, A. Tiengo, and A. Avogaro, “Detection of coronary artery disease in asymptomatic patients with type 2 diabetes mellitus,” Journal of the American College of Cardiology, vol. 47, no. 1, pp. 65–71, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Hammoud, J. F. Tanguay, and M. G. Bourassa, “Management of coronary artery disease: therapeutic options in patients with diabetes,” Journal of the American College of Cardiology, vol. 36, no. 2, pp. 355–365, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Franklin, R. J. Goldberg, F. Spencer et al., “Implications of diabetes in patients with acute coronary syndromes. The Global Registry of Acute Coronary Events,” Archives of Internal Medicine, vol. 164, no. 13, pp. 1457–1463, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. S. M. Haffner, S. Lehto, T. Rönnemaa, K. Pyörälä, and M. Laakso, “Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction,” The New England Journal of Medicine, vol. 339, no. 4, pp. 229–234, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. M. R. Carnethon, M. L. Biggs, J. Barzilay et al., “Diabetes and coronary heart disease as risk factors for mortality in older adults,” The American Journal of Medicine, vol. 123, no. 6, pp. 556.e1–556.e9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Malmberg, S. Yusuf, H. C. Gerstein et al., “Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry,” Circulation, vol. 102, no. 1019, pp. 1014–9, 2000. View at Publisher · View at Google Scholar
  35. S. G. Wannamethee, A. G. Shaper, P. H. Whincup, L. Lennon, and N. Sattar, “Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men: influence of age at onset, diabetes duration, and established and novel risk factors,” Archives of Internal Medicine, vol. 171, no. 5, pp. 404–410, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. U. Bulugahapitiya, S. Siyambalapitiya, J. Sithole, and I. Idris, “Is diabetes a coronary risk equivalent? Systematic review and meta-analysis,” Diabetic Medicine, vol. 26, no. 2, pp. 142–148, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Sattar, “Revisiting the links between glycaemia, diabetes and cardiovascular disease,” Diabetologia, vol. 56, no. 4, pp. 686–695, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. N. J. Stone, J. G. Robinson, A. H. Lichtenstein et al., “2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults,” Circulation, vol. 129, no. 25 Supplement 2, pp. S1–S45, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. M. F. Piepoli, A. W. Hoes, S. Agewall et al., “2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts),” European Heart Journal, vol. 37, no. 29, pp. 2315–2381, 2016. View at Publisher · View at Google Scholar · View at Scopus
  40. S. M. Haffner, L. Mykkänen, A. Festa, J. P. Burke, and M. P. Stern, “Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state,” Circulation, vol. 101, no. 9, pp. 975–980, 2000. View at Publisher · View at Google Scholar
  41. P. Gæde, H. Lund-Andersen, H.-H. Parving, and O. Pedersen, “Effect of a multifactorial intervention on mortality in type 2 diabetes,” New England Journal of Medicine, vol. 358, no. 6, pp. 580–591, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. F. J. T. Wackers, L. H. Young, S. E. Inzucchi et al., “Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study,” Diabetes Care, vol. 27, no. 8, pp. 1954–1961, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. P. T. O’Gara, F. G. Kushner, D. D. Ascheim et al., “2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines,” Circulation, vol. 127, no. 4, pp. 529–555, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. L. M. Phillips, R. Hachamovitch, D. S. Berman et al., “Lessons learned from MPI and physiologic testing in randomized trials of stable ischemic heart disease: COURAGE, BARI 2D, FAME, and ISCHEMIA,” Journal of Nuclear Cardiology, vol. 20, no. 6, pp. 969–975, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. G. W. Stone, J. S. Hochman, D. O. Williams et al., “Medical therapy with versus without revascularization in stable patients with moderate and severe ischemia: the case for community equipoise,” Journal of the American College of Cardiology, vol. 67, no. 1, pp. 81–99, 2016. View at Publisher · View at Google Scholar · View at Scopus
  46. A. L. Cochrane and W. W. Holland, “Validation of screening procedures,” British Medical Bulletin, vol. 27, no. 1, pp. 3–8, 1971. View at Publisher · View at Google Scholar
  47. D. M. Nathan, P. A. Cleary, J.-Y. C. Backlund et al., “Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes,” The New England Journal of Medicine, vol. 353, no. 25, pp. 2643–2653, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. P. C. Deedwania and E. V. Carbajal, “Silent myocardial ischemia. A clinical perspective,” Archives of Internal Medicine, vol. 151, no. 12, pp. 2373–2382, 1991. View at Publisher · View at Google Scholar · View at Scopus
  49. M. J. Budoff, P. Raggi, G. A. Beller et al., “Noninvasive cardiovascular risk assessment of the asymptomatic diabetic patient: The Imaging Council of the American College of Cardiology,” JACC Cardiovascular Imaging, vol. 9, no. 2, pp. 176–192, 2016. View at Publisher · View at Google Scholar · View at Scopus
  50. S. D. Fihn, J. M. Gardin, J. Abrams et al., “2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons,” Circulation, vol. 126, no. 25, pp. e354–e471, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. C. Paillole, J. Ruiz, J. M. Juliard, H. Leblanc, R. Gourgon, and P. Passa, “Detection of coronary artery disease in diabetic patients,” Diabetologia, vol. 38, no. 6, pp. 726–731, 1995. View at Publisher · View at Google Scholar · View at Scopus
  52. P. J. Scanlon, D. P. Faxon, A. M. Audet et al., “ACC/AHA guidelines for coronary angiography: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions,” Circulation, vol. 99, no. 17, pp. 2345–2357, 1999. View at Publisher · View at Google Scholar
  53. E. A. Caracciolo, B. R. Chaitman, S. A. Forman et al., “Diabetics with coronary disease have a prevalence of asymptomatic ischemia during exercise treadmill testing and ambulatory ischemia monitoring similar to that of nondiabetic patients. An ACIP database study. ACIP investigators. Asymptomatic cardiac ischemia pilot investigators,” Circulation, vol. 93, no. 12, pp. 2097–2105, 1996. View at Publisher · View at Google Scholar
  54. C. Kim, Y. S. Kwok, P. Heagerty, and R. Redberg, “Pharmacologic stress testing for coronary disease diagnosis: a meta-analysis,” American Heart Journal, vol. 142, no. 6, pp. 934–944, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Bacci, M. Villella, A. Villella et al., “Screening for silent myocardial ischaemia in type 2 diabetic patients with additional atherogenic risk factors: applicability and accuracy of the exercise stress test,” European Journal of Endocrinology, vol. 147, no. 5, pp. 649–654, 2002. View at Publisher · View at Google Scholar
  56. W. Acampa, V. Cantoni, R. Green et al., “Prognostic value of normal stress myocardial perfusion imaging in diabetic patients: a meta-analysis,” Journal of Nuclear Cardiology, vol. 21, no. 5, pp. 893–902, 2014. View at Publisher · View at Google Scholar · View at Scopus
  57. R. Nakazato, D. S. Berman, E. Alexanderson, and P. Slomka, “Myocardial perfusion imaging with PET,” Imaging in Medicine, vol. 5, no. 1, pp. 35–46, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. T. H. Marwick, C. Case, S. Sawada, C. Vasey, L. Short, and M. Lauer, “Use of stress echocardiography to predict mortality in patients with diabetes and known or suspected coronary artery disease,” Diabetes Care, vol. 25, no. 6, pp. 1042–1048, 2002. View at Publisher · View at Google Scholar · View at Scopus
  59. L. Cortigiani, R. Bigi, R. Sicari, P. Landi, F. Bovenzi, and E. Picano, “Prognostic value of pharmacological stress echocardiography in diabetic and nondiabetic patients with known or suspected coronary artery disease,” Journal of the American College of Cardiology, vol. 47, no. 3, pp. 605–610, 2006. View at Publisher · View at Google Scholar · View at Scopus
  60. G. Di Leo, E. Fisci, F. Secchi et al., “Diagnostic accuracy of magnetic resonance angiography for detection of coronary artery disease: a systematic review and meta-analysis,” European Radiology, vol. 26, no. 10, pp. 3706–3718, 2016. View at Publisher · View at Google Scholar · View at Scopus
  61. A. J. H. A. Scholte, J. D. Schuijf, A. V. Kharagjitsingh et al., “Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes,” Heart, vol. 94, no. 3, pp. 290–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  62. I. Sarikaya, “Cardiac applications of PET,” Nuclear Medicine Communications, vol. 36, no. 10, pp. 971–985, 2015. View at Publisher · View at Google Scholar · View at Scopus
  63. X. Kang, D. S. Berman, H. Lewin et al., “Comparative ability of myocardial perfusion single-photon emission computed tomography to detect coronary artery disease in patients with and without diabetes mellitus,” American Heart Journal, vol. 137, no. 5, pp. 949–957, 1999. View at Publisher · View at Google Scholar · View at Scopus
  64. R. Hachamovitch, X. Kang, A. M. Amanullah et al., “Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly,” Circulation, vol. 120, no. 22, pp. 2197–2206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Giri, L. J. Shaw, D. R. Murthy et al., “Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease,” Circulation, vol. 105, no. 1, pp. 32–40, 2002. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Rajagopalan, T. D. Miller, D. O. Hodge, R. L. Frye, and R. J. Gibbons, “Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging,” Journal of the American College of Cardiology, vol. 45, no. 1, pp. 43–49, 2005. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Malhotra, R. Sharma, D. E. Kliner, W. P. Follansbee, and P. Soman, “Relationship between silent myocardial ischemia and coronary artery disease risk factors,” Journal of Nuclear Cardiology, vol. 20, no. 5, pp. 731–738, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. D. V. Anand, E. Lim, D. Hopkins et al., “Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy,” European Heart Journal, vol. 27, no. 6, pp. 713–721, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. J. Stolzenberg, “Dilatation of left ventricular cavity on stress thallium scan as an indicator of ischemic disease,” Clinical Nuclear Medicine, vol. 5, no. 7, pp. 289–291, 1980. View at Publisher · View at Google Scholar
  70. M. G. McLaughlin and P. G. Danias, “Transient ischemic dilation: a powerful diagnostic and prognostic finding of stress myocardial perfusion imaging,” Journal of Nuclear Cardiology, vol. 9, no. 6, pp. 663–667, 2002. View at Publisher · View at Google Scholar · View at Scopus
  71. A. T. Weiss, D. S. Berman, A. S. Lew et al., “Transient ischemic dilation of the left ventricle on stress thallium-201 scintigraphy: a marker of severe and extensive coronary artery disease,” Journal of the American College of Cardiology, vol. 9, no. 4, pp. 752–759, 1987. View at Publisher · View at Google Scholar
  72. C. Valdiviezo, A. A. Motivala, R. Hachamovitch et al., “The significance of transient ischemic dilation in the setting of otherwise normal SPECT radionuclide myocardial perfusion images,” Journal of Nuclear Cardiology, vol. 18, no. 2, pp. 220–229, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. W. T. Halligan, P. B. Morris, U. J. Schoepf et al., “Transient ischemic dilation of the left ventricle on SPECT: correlation with findings at coronary CT angiography,” Journal of Nuclear Medicine, vol. 55, no. 6, pp. 917–922, 2014. View at Publisher · View at Google Scholar · View at Scopus
  74. M. Petretta, W. Acampa, S. Daniele, M. P. Petretta, M. Plaitano, and A. Cuocolo, “Transient ischemic dilation in patients with diabetes mellitus: prognostic value and effect on clinical outcome after coronary revascularization,” Circulation Cardiovascular Imaging, vol. 6, no. 6, pp. 908–915, 2013. View at Publisher · View at Google Scholar · View at Scopus
  75. B. Fallahi, D. Beiki, A. Fard-Esfahani et al., “The additive value of transient left ventricular dilation using two-day dipyridamole 99mTc-MIBI SPET for screening coronary artery disease in patients with otherwise normal myocardial perfusion: a comparison between diabetic and non-diabetic cases,” Hellenic journal of nuclear medicine, vol. 13, no. 3, pp. 246–252, 2010. View at Google Scholar
  76. M. G. Sutton and N. Sharpe, “Left ventricular remodeling after myocardial infarction: pathophysiology and therapy,” Circulation, vol. 101, no. 25, pp. 2981–2988, 2000. View at Publisher · View at Google Scholar
  77. H. D. White, R. M. Norris, M. A. Brown, P. W. Brandt, R. M. Whitlock, and C. J. Wild, “Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction,” Circulation, vol. 76, no. 1, pp. 44–51, 1987. View at Publisher · View at Google Scholar
  78. B. Knap, G. Juznic, A. F. Bren, G. Drzewiecki, and A. Noordergraaf, “Elongation as a new shape index for the left ventricle,” The International Journal of Cardiovascular Imaging, vol. 18, no. 6, pp. 421–430, 2002. View at Google Scholar
  79. H. F. J. Mannaerts, J. A. van der Heide, O. Kamp, M. G. Stoel, J. Twisk, and C. A. Visser, “Early identification of left ventricular remodelling after myocardial infarction, assessed by transthoracic 3D echocardiography,” European Heart Journal, vol. 25, no. 8, pp. 680–687, 2004. View at Publisher · View at Google Scholar · View at Scopus
  80. R. Bomb, S. Kumar, and A. Chockalingam, “Coronary artery disease detection - limitations of stress testing in left ventricular dysfunction,” World Journal of Cardiology, vol. 9, no. 4, pp. 304–311, 2017. View at Publisher · View at Google Scholar
  81. A. Abidov, P. J. Slomka, H. Nishina et al., “Left ventricular shape index assessed by gated stress myocardial perfusion SPECT: initial description of a new variable,” Journal of Nuclear Cardiology, vol. 13, no. 5, pp. 652–659, 2006. View at Publisher · View at Google Scholar · View at Scopus
  82. G. Germano, H. Kiat, P. B. Kavanagh et al., “Automatic quantification of ejection fraction from gated myocardial perfusion SPECT,” Journal of Nuclear Medicine, vol. 36, no. 11, pp. 2138–2147, 1995. View at Google Scholar
  83. A. Abidov, P. J. Slomka, H. Nishina et al., “Focal stress induced LV geometry changes independently predict presence of the angiographically significant CAD in patients undergoing myocardial perfusion SPECT,” Journal of the American College of Cardiology, vol. 45, p. 15A, 2005. View at Google Scholar
  84. P. Slomka, D. S. Berman, E. Alexanderson, and G. Germano, “The role of PET quantification in cardiovascular imaging,” Clinical and Translational Imaging, vol. 2, no. 4, pp. 343–358, 2014. View at Publisher · View at Google Scholar · View at Scopus
  85. V. L. Murthy, M. Naya, C. R. Foster et al., “Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus,” Circulation, vol. 126, no. 15, pp. 1858–1868, 2012. View at Publisher · View at Google Scholar · View at Scopus
  86. B. A. Mc Ardle, T. F. Dowsley, R. A. deKemp, G. A. Wells, and R. S. Beanlands, “Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease?: a systematic review and meta-analysis,” Journal of the American College of Cardiology, vol. 60, no. 18, pp. 1828–1837, 2012. View at Publisher · View at Google Scholar · View at Scopus
  87. A. Elhendy, J. M. Tsutsui, E. L. O’Leary, F. Xie, A. C. McGrain, and T. R. Porter, “Noninvasive diagnosis of coronary artery disease in patients with diabetes by dobutamine stress real-time myocardial contrast perfusion imaging,” Diabetes Care, vol. 28, no. 7, pp. 1662–7, 2005. View at Publisher · View at Google Scholar · View at Scopus
  88. S. S. Abdelmoneim, M. Bernier, A. Dhoble et al., “Assessment of myocardial perfusion during adenosine stress using real time three-dimensional and two-dimensional myocardial contrast echocardiography: comparison with single-photon emission computed tomography,” Echocardiography, vol. 27, no. 4, pp. 421–429, 2010. View at Publisher · View at Google Scholar · View at Scopus
  89. E. B. Turkbey, J.-Y. C. Backlund, S. Genuth et al., “Myocardial structure, function, and scar in patients with type 1 diabetes mellitus,” Circulation, vol. 124, no. 16, pp. 1737–1746, 2011. View at Publisher · View at Google Scholar · View at Scopus
  90. Y. Ichikawa, H. Sakuma, N. Suzawa et al., “Late gadolinium-enhanced magnetic resonance imaging in acute and chronic myocardial infarction: improved prediction of regional myocardial contraction in the chronic state by measuring thickness of nonenhanced myocardium,” Journal of the American College of Cardiology, vol. 45, no. 6, pp. 901–909, 2005. View at Publisher · View at Google Scholar · View at Scopus
  91. J. A. Rumberger, D. B. Simons, L. A. Fitzpatrick, P. F. Sheedy, and R. S. Schwartz, “Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study,” Circulation, vol. 92, no. 8, pp. 2157–2162, 1995. View at Publisher · View at Google Scholar
  92. M. J. Budoff, S. Möhlenkamp, R. McClelland et al., “A comparison of outcomes with coronary artery calcium scanning in unselected populations: the Multi-Ethnic Study of Atherosclerosis (MESA) and Heinz Nixdorf RECALL study (HNR),” Journal of Cardiovascular Computed Tomography, vol. 7, no. 3, pp. 182–191, 2013. View at Publisher · View at Google Scholar · View at Scopus
  93. N. D. Wong, M. G. Sciammarella, D. Polk et al., “The metabolic syndrome, diabetes, and subclinical atherosclerosis assessed by coronary calcium,” Journal of the American College of Cardiology, vol. 41, no. 9, pp. 1547–1553, 2003. View at Publisher · View at Google Scholar · View at Scopus
  94. S. Schurgin, S. Rich, and T. Mazzone, “Increased prevalence of significant coronary artery calcification in patients with diabetes,” Diabetes Care, vol. 24, no. 2, pp. 335–338, 2001. View at Publisher · View at Google Scholar
  95. E. Khaleeli, S. R. Peters, K. Bobrowsky, R. J. Oudiz, J. Y. Ko, and M. J. Budoff, “Diabetes and the associated incidence of subclinical atherosclerosis and coronary artery disease: Implications for management,” American Heart Journal, vol. 141, no. 4, pp. 637–644, 2001. View at Publisher · View at Google Scholar · View at Scopus
  96. C. H. Mielke, J. P. Shields, and L. D. Broemeling, “Coronary artery calcium, coronary artery disease, and diabetes,” Diabetes Research and Clinical Practice, vol. 53, no. 1, pp. 55–61, 2001. View at Publisher · View at Google Scholar · View at Scopus
  97. Z. X. He, T. D. Hedrick, C. M. Pratt et al., “Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia,” Circulation, vol. 101, no. 3, pp. 244–251, 2000. View at Publisher · View at Google Scholar
  98. N. D. Wong, A. Rozanski, H. Gransar et al., “Metabolic syndrome and diabetes are associated with an increased likelihood of inducible myocardial ischemia among patients with subclinical atherosclerosis,” Diabetes Care, vol. 28, no. 6, pp. 1445–1450, 2005. View at Publisher · View at Google Scholar · View at Scopus
  99. J. Yeboah, R. Erbel, J. C. Delaney et al., “Development of a new diabetes risk prediction tool for incident coronary heart disease events: The Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study,” Atherosclerosis, vol. 236, no. 2, pp. 411–417, 2014. View at Publisher · View at Google Scholar · View at Scopus
  100. G.-M. Park, J.-H. Lee, S.-W. Lee et al., “Comparison of coronary computed tomographic angiographic findings in asymptomatic subjects with versus without diabetes mellitus,” The American Journal of Cardiology, vol. 116, no. 3, pp. 372–378, 2015. View at Publisher · View at Google Scholar · View at Scopus
  101. S. Kiramijyan, N. Ahmadi, H. Isma'eel et al., “Impact of coronary artery calcium progression and statin therapy on clinical outcome in subjects with and without diabetes mellitus,” The American Journal of Cardiology, vol. 111, no. 3, pp. 356–361, 2013. View at Publisher · View at Google Scholar · View at Scopus
  102. P. Raggi, L. J. Shaw, D. S. Berman, and T. Q. Callister, “Prognostic value of coronary artery calcium screening in subjects with and without diabetes,” Journal of the American College of Cardiology, vol. 43, no. 9, pp. 1663–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  103. I. Gottlieb, J. M. Miller, A. Arbab-Zadeh et al., “The absence of coronary calcification does not exclude obstructive coronary artery disease or the need for revascularization in patients referred for conventional coronary angiography,” Journal of the American College of Cardiology, vol. 55, no. 7, pp. 627–634, 2010. View at Publisher · View at Google Scholar · View at Scopus
  104. D. C. Goff, D. M. Lloyd-Jones, G. Bennett et al., “2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines,” Journal of the American College of Cardiology, vol. 63, Part B, no. 25, pp. 2935–2959, 2014. View at Publisher · View at Google Scholar · View at Scopus
  105. P. Gueret, J.-F. Deux, L. Bonello et al., “Diagnostic performance of computed tomography coronary angiography (from the Prospective National Multicenter Multivendor EVASCAN Study),” The American Journal of Cardiology, vol. 111, no. 4, pp. 471–478, 2013. View at Publisher · View at Google Scholar · View at Scopus
  106. J. D. Schuijf, J. J. Bax, L. J. Shaw et al., “Meta-analysis of comparative diagnostic performance of magnetic resonance imaging and multislice computed tomography for noninvasive coronary angiography,” American Heart Journal, vol. 151, no. 2, pp. 404–411, 2006. View at Publisher · View at Google Scholar · View at Scopus
  107. M. J. Wolk, S. R. Bailey, J. U. Doherty et al., “ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons,” Journal of the American College of Cardiology, vol. 63, no. 4, pp. 380–406, 2014. View at Publisher · View at Google Scholar · View at Scopus
  108. American Diabetes Association, “9. Cardiovascular disease and risk management,” Diabetes Care, vol. 40, Supplement 1, pp. S75–S87, 2017. View at Publisher · View at Google Scholar
  109. A. Berrington de González, M. Mahesh, K.-P. Kim et al., “Projected cancer risks from computed tomographic scans performed in the United States in 2007,” Archives of Internal Medicine, vol. 169, no. 22, pp. 2071–2077, 2009. View at Publisher · View at Google Scholar · View at Scopus
  110. M. Pignone, M. J. Alberts, J. A. Colwell et al., “Aspirin for primary prevention of cardiovascular events in people with diabetes,” Journal of the American College of Cardiology, vol. 55, no. 25, pp. 2878–2886, 2010. View at Publisher · View at Google Scholar · View at Scopus
  111. M. G. Silverman, M. J. Blaha, M. J. Budoff et al., “Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes,” Diabetes Care, vol. 35, no. 3, pp. 624–626, 2012. View at Publisher · View at Google Scholar · View at Scopus
  112. A. L. Catapano, I. Graham, G. De Backer et al., “2016 ESC/EAS guidelines for the management of dyslipidaemias,” European Heart Journal, vol. 37, no. 39, pp. 2999–3058, 2016. View at Publisher · View at Google Scholar · View at Scopus
  113. R. Hachamovitch, D. S. Berman, L. J. Shaw et al., “Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction,” Circulation, vol. 97, no. 6, pp. 535–543, 1998. View at Publisher · View at Google Scholar
  114. D. V. Rados, L. C. Pinto, C. B. Leitão, and J. L. Gross, “Screening for coronary artery disease in patients with type 2 diabetes: a meta-analysis and trial sequential analysis,” BMJ Open, vol. 7, no. 5, article e015089, 2017. View at Publisher · View at Google Scholar
  115. G. A. Beller and J. M. Bourque, “Screening asymptomatic patients with type 2 diabetes: the debates persist,” Journal of Nuclear Cardiology, vol. 22, no. 1236, pp. 1233–6, 2015. View at Publisher · View at Google Scholar · View at Scopus
  116. E. Faglia, M. Manuela, Q. Antonella et al., “Risk reduction of cardiac events by screening of unknown asymptomatic coronary artery disease in subjects with type 2 diabetes mellitus at high cardiovascular risk: an open-label randomized pilot study,” American Heart Journal, vol. 149, no. 2, pp. e1–e6, 2005. View at Publisher · View at Google Scholar · View at Scopus
  117. I. H. Young, F. J. T. Wackers, D. A. Chyun et al., “Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial,” JAMA, vol. 301, no. 15, pp. 1547–1555, 2009. View at Publisher · View at Google Scholar · View at Scopus
  118. I. M. Lièvre, P. Moulin, C. Thivolet et al., “Detection of silent myocardial ischemia in asymptomatic patients with diabetes: results of a randomized trial and meta-analysis assessing the effectiveness of systematic screening,” Trials, vol. 12, no. 1, p. 23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  119. J. B. Muhlestein, D. L. Lappé, J. A. C. Lima et al., “Effect of screening for coronary artery disease using CT angiography on mortality and cardiac events in high-risk patients with diabetes. The FACTOR-64 randomized clinical trial,” JAMA, vol. 312, no. 21, pp. 2234–2243, 2014. View at Publisher · View at Google Scholar · View at Scopus
  120. F. Turrini, S. Scarlini, C. Mannucci et al., “Does coronary atherosclerosis deserve to be diagnosed early in diabetic patients? The DADDY-D trial. Screening diabetic patients for unknown coronary disease,” European Journal of Internal Medicine, vol. 26, no. 6, pp. 407–413, 2015. View at Publisher · View at Google Scholar · View at Scopus
  121. M. J. Zellweger, M. Maraun, H. H. Osterhues et al., “Progression to overt or silent CAD in asymptomatic patients with diabetes mellitus at high coronary risk: main findings of the prospective multicenter BARDOT trial with a pilot randomized treatment substudy,” JACC: Cardiovascular Imaging, vol. 7, no. 10, pp. 1001–10, 2014. View at Publisher · View at Google Scholar · View at Scopus
  122. P. A. McCullough, P. Fazel, and J. W. Choi, “Screening, diagnosis, and management of CAD in asymptomatic diabetic patients,” JACC Cardiovascular Imaging, vol. 7, no. 10, pp. 1011-1012, 2014. View at Publisher · View at Google Scholar · View at Scopus
  123. W. Acampa, M. Petretta, L. Evangelista et al., “Myocardial perfusion imaging and risk classification for coronary heart disease in diabetic patients. The IDIS study: a prospective, multicentre trial,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 39, no. 3, pp. 387–395, 2012. View at Publisher · View at Google Scholar · View at Scopus
  124. W. Acampa, M. Petretta, S. Daniele et al., “Incremental prognostic value of stress myocardial perfusion imaging in asymptomatic diabetic patients,” Atherosclerosis, vol. 227, no. 2, pp. 307–312, 2013. View at Publisher · View at Google Scholar · View at Scopus
  125. L. Zhang, H. Li, S. Zhang, L. M. Jaacks, Y. Li, and L. Ji, “Silent myocardial ischemia detected by single photon emission computed tomography (SPECT) and risk of cardiac events among asymptomatic patients with type 2 diabetes: a meta-analysis of prospective studies,” Journal of diabetes and its complications, vol. 28, no. 3, pp. 413–418, 2014. View at Publisher · View at Google Scholar · View at Scopus
  126. M. Petretta and A. Cuocolo, “Screening asymptomatic patients with type 2 diabetes is recommended: Pro,” Journal of Nuclear Cardiology, vol. 22, no. 6, pp. 1225–1228, 2015. View at Publisher · View at Google Scholar · View at Scopus
  127. R. J. Gibbons, “Screening asymptomatic patients with type 2 diabetes is recommended-Con,” Journal of Nuclear Cardiology, vol. 22, no. 6, pp. 1229–1232, 2015. View at Publisher · View at Google Scholar · View at Scopus
  128. C. J. Pepine, B. Sharaf, T. C. Andrews et al., “Relation between clinical, angiographic and ischemic findings at baseline and ischemia-related adverse outcomes at 1 year in the Asymptomatic Cardiac Ischemia Pilot study. ACIP Study Group,” Journal of the American College of Cardiology, vol. 29, no. 7, pp. 1483–1489, 1997. View at Publisher · View at Google Scholar · View at Scopus
  129. G. Vanzetto, O. Ormezzano, D. Fagret, M. Comet, B. Denis, and J. Machecourt, “Long-term additive prognostic value of thallium-201 myocardial perfusion imaging over clinical and exercise stress test in low to intermediate risk patients,” Circulation, vol. 100, no. 14, pp. 1521–1527, 1999. View at Publisher · View at Google Scholar
  130. P. C. Deedwania, “Silent ischemia predicts poor outcome in high-risk healthy men,” Journal of the American College of Cardiology, vol. 38, no. 1, pp. 80–83, 2001. View at Publisher · View at Google Scholar · View at Scopus
  131. L. J. Shaw, M. D. Cerqueira, M. M. Brooks et al., “Impact of left ventricular function and the extent of ischemia and scar by stress myocardial perfusion imaging on prognosis and therapeutic risk reduction in diabetic patients with coronary artery disease: results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial,” Journal of Nuclear Cardiology, vol. 19, no. 4, pp. 658–669, 2012. View at Publisher · View at Google Scholar · View at Scopus
  132. N. Aldweib, K. Negishi, R. Hachamovitch, W. A. Jaber, S. Seicean, and T. H. Marwick, “Impact of repeat myocardial revascularization on outcome in patients with silent ischemia after previous revascularization,” Journal of the American College of Cardiology, vol. 61, no. 15, pp. 1616–1623, 2013. View at Publisher · View at Google Scholar · View at Scopus
  133. G. B. J. Mancini, P. M. Hartigan, L. J. Shaw et al., “Predicting outcome in the COURAGE trial (clinical outcomes utilizing revascularization and aggressive drug evaluation): coronary anatomy versus ischemia,” JACC: Cardiovascular Interventions, vol. 7, no. 2, pp. 195–201, 2014. View at Publisher · View at Google Scholar · View at Scopus
  134. W. Hueb, P. R. Soares, B. J. Gersh et al., “The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one-year results,” Journal of the American College of Cardiology, vol. 43, no. 10, pp. 1743–1751, 2004. View at Publisher · View at Google Scholar · View at Scopus
  135. W. E. Boden, R. A. O'Rourke, K. K. Teo et al., “Optimal medical therapy with or without pci for stable coronary disease,” The New England Journal of Medicine, vol. 356, no. 15, pp. 1503–1516, 2007. View at Publisher · View at Google Scholar · View at Scopus
  136. R. Mori Brooks, R. M. Hardison, S. F. Kelsey et al., “A randomized trial of therapies for type 2 diabetes and coronary artery disease,” The New England Journal of Medicine, vol. 360, no. 24, pp. 2503–2515, 2009. View at Publisher · View at Google Scholar · View at Scopus
  137. S. P. Sedlis, P. M. Hartigan, K. K. Teo et al., “Effect of PCI on long-term survival in patients with stable ischemic heart disease,” The New England Journal of Medicine, vol. 373, no. 20, pp. 1937–1946, 2015. View at Publisher · View at Google Scholar · View at Scopus
  138. B. R. Chaitman, R. M. Hardison, D. Adler et al., “The bypass angioplasty revascularization investigation 2 diabetes randomized trial of different treatment strategies in type 2 diabetes mellitus with stable ischemic heart disease: impact of treatment strategy on cardiac mortality and myocardial infarction,” Circulation, vol. 120, no. 25, pp. 2529–2540, 2009. View at Publisher · View at Google Scholar · View at Scopus
  139. M. M. Brooks, B. R. Chaitman, R. W. Nesto et al., “Clinical and angiographic risk stratification and differential impact on treatment outcomes in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial,” Circulation, vol. 126, no. 17, pp. 2115–2124, 2012. View at Publisher · View at Google Scholar · View at Scopus
  140. N. H. J. Pijls, B. de Bruyne, K. Peels et al., “Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses,” The New England Journal of Medicine, vol. 334, no. 26, pp. 1703–1708, 1996. View at Publisher · View at Google Scholar · View at Scopus
  141. B. De Bruyne, N. H. J. Pijls, B. Kalesan et al., “Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease,” The New England journal of Medicine, vol. 367, no. 11, pp. 991–1001, 2012. View at Publisher · View at Google Scholar · View at Scopus
  142. H. C. Wijeysundera and D. T. Ko, “Does percutaneous coronary intervention reduce mortality in patients with stable chronic angina,” Circulation: Cardiovascular Quality and Outcomes, vol. 2, no. 2, pp. 123–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  143. T. A. Trikalinos, A. A. Alsheikh-Ali, A. Tatsioni, B. K. Nallamothu, D. M. Kent, and A. Kastrati, “Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis,” The Lancet, vol. 373, no. 9667, pp. 911–918, 2009. View at Publisher · View at Google Scholar · View at Scopus
  144. K. Stergiopoulos, W. E. Boden, P. Hartigan et al., “Percutaneous coronary intervention outcomes in patients with stable obstructive coronary artery disease and myocardial ischemia: a collaborative meta-analysis of contemporary randomized clinical trials,” JAMA Internal Medicine, vol. 174, no. 2, pp. 232–240, 2014. View at Publisher · View at Google Scholar · View at Scopus
  145. F. J. T. Wackers, D. A. Chyun, L. H. Young et al., “Resolution of asymptomatic myocardial ischemia in patients with type 2 diabetes in the detection of ischemia in asymptomatic diabetics (DIAD) study,” Diabetes care, vol. 30, no. 11, pp. 2892–2898, 2007. View at Publisher · View at Google Scholar · View at Scopus
  146. W. S. Weintraub, W. E. Boden, Z. Zhang et al., “Cost-effectiveness of percutaneous coronary intervention in optimally treated stable coronary patients. clinical perspective,” Circulation: Cardiovascular Quality and Outcomes, vol. 1, no. 1, pp. 12–20, 2008. View at Publisher · View at Google Scholar · View at Scopus
  147. M. A. Hlatky, D. B. Boothroyd, K. A. Melsop et al., “Economic outcomes of treatment strategies for type 2 diabetes mellitus and coronary artery disease in the bypass angioplasty revascularization investigation 2 diabetes trial,” Circulation, vol. 120, no. 25, pp. 2550–2558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  148. J. J. Bax, L. H. Young, R. L. Frye, R. O. Bonow, H. O. Steinberg, and E. J. Barrett, “Screening for coronary artery disease in patients with diabetes,” Diabetes Care, vol. 30, no. 10, pp. 2729–2736, 2007. View at Publisher · View at Google Scholar · View at Scopus
  149. L. Rydén, P. J. Grant, S. D. Anker et al., “ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD),” European Heart Journal, vol. 34, no. 39, pp. 3035–3087, 2013. View at Publisher · View at Google Scholar · View at Scopus
  150. V. A. Moyer and U.S. Preventive Services Task Force, “Screening for coronary heart disease with electrocardiography: U.S. Preventive Services Task Force recommendation statement,” Annals of Internal Medicine, vol. 157, no. 7, pp. 512–518, 2012. View at Publisher · View at Google Scholar
  151. R. J. Gibbons, G. J. Balady, J. T. Bricker et al., “ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (committee to update the 1997 exercise testing guidelines),” Journal of the American College of Cardiology, vol. 40, no. 8, pp. 1531–1540, 2002. View at Publisher · View at Google Scholar · View at Scopus
  152. R. Chou and High Value Care Task Force of the American College of Physicians, “Cardiac screening with electrocardiography, stress echocardiography, or myocardial perfusion imaging: advice for high-value care from the American College of Physicians,” Annals of Internal Medicine, vol. 162, no. 6, pp. 438–447, 2015. View at Publisher · View at Google Scholar · View at Scopus
  153. H. C. Wijeysundera, M. C. Bennell, F. Qiu et al., “Comparative-effectiveness of revascularization versus routine medical therapy for stable ischemic heart disease: a population-based study,” Journal of General Internal Medicine, vol. 29, no. 7, pp. 1031–1039, 2014. View at Publisher · View at Google Scholar · View at Scopus
  154. R. Hachamovitch, S. W. Hayes, J. D. Friedman, I. Cohen, and D. S. Berman, “Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography,” Circulation, vol. 107, no. 23, pp. 2900–2907, 2003. View at Publisher · View at Google Scholar · View at Scopus
  155. L. J. Shaw, D. S. Berman, D. J. Maron et al., “Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial nuclear substudy,” Circulation, vol. 117, no. 10, pp. 1283–1291, 2008. View at Publisher · View at Google Scholar · View at Scopus
  156. L. J. Shaw, W. S. Weintraub, D. J. Maron et al., “Baseline stress myocardial perfusion imaging results and outcomes in patients with stable ischemic heart disease randomized to optimal medical therapy with or without percutaneous coronary intervention,” American Heart Journal, vol. 164, no. 2, pp. 243–250, 2012. View at Publisher · View at Google Scholar · View at Scopus
  157. M. B. Rothberg, “Coronary artery disease as clogged pipes: a misconceptual model,” Circulation: Cardiovascular Quality and Outcomes, vol. 6, no. 1, pp. 129–132, 2013. View at Publisher · View at Google Scholar · View at Scopus
  158. G. W. Stone, A. Maehara, A. J. Lansky et al., “A prospective natural-history study of coronary atherosclerosis,” The New England Journal of Medicine, vol. 364, no. 3, pp. 226–235, 2011. View at Publisher · View at Google Scholar · View at Scopus
  159. S.-J. Park, S.-J. Kang, J.-M. Ahn et al., “Visual-functional mismatch between coronary angiography and fractional flow reserve,” JACC: Cardiovascular Interventions, vol. 5, no. 10, pp. 1029–1036, 2012. View at Publisher · View at Google Scholar · View at Scopus
  160. D. G. Katritsis, J. Pantos, and E. Efstathopoulos, “Hemodynamic factors and atheromatic plaque rupture in the coronary arteries: from vulnerable plaque to vulnerable coronary segment,” Coronary Artery Disease, vol. 18, no. 3, pp. 229–237, 2007. View at Publisher · View at Google Scholar · View at Scopus
  161. M. J. Zellweger, C. Kaiser, H. P. Brunner-La Rocca et al., “Value and limitations of target-vessel ischemia in predicting late clinical events after drug-eluting stent implantation,” Journal of Nuclear Medicine, vol. 49, no. 4, pp. 550–556, 2008. View at Publisher · View at Google Scholar · View at Scopus
  162. A. J. Kirtane, A. Gupta, S. Iyengar et al., “Safety and efficacy of drug-eluting and bare metal stents,” Circulation, vol. 119, no. 25, pp. 3198–3206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  163. T. Palmerini, G. Biondi-Zoccai, D. Della Riva et al., “Clinical outcomes with bioabsorbable polymer-versus durable polymer-based drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis,” Journal of the American College of Cardiology, vol. 63, no. 4, pp. 299–307, 2014. View at Publisher · View at Google Scholar · View at Scopus