The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration
Table 1
Demographic and clinical data of all patients.
No-DN
CIC-DN
BP-DN
CIC-NDRD
BP-NDRD
N
130
108
30
80
22
Demographic characteristics
Male sex—n (%)
65 (50)
69 (64)
21 (70)
49 (61)
14 (64)
Age—year
71 (63–75)
71 (62–76)
61 (57–69)
61 (48–74)
61 (55–78)
Clinical characteristics
Body mass index—kg/m2
31.1 (28–35)
29.8 (27–35)
29.9 (25–35)
24.5 (21–27)
27 (24–32)
Hypertension
Number of AHM
3 (2–3)
3 (2–4)
3 (2–5)
3 (1.5–4)
2 (2–4)
Blood pressure—mmHg
Systolic
129 (120–140)
135 (120–156)
140 (130–150)
135 (120–145)
140 (128–153)
Diastolic
70 (66–80)
70 (60–80)
75 (70–80)
70 (60–80)
70 (64–80)
Diabetes mellitus
Time from diagnosis—year
16 (13–20)
21 (15–29)
14 (9–20)
—
—
HbA1c—%
7.0 (6.4–8.1)
7.3 (6.8–8.2)
7.6 (6.7–8.8)
5.6 (5.4–5.7)
5.6 (5.1–6.2)
Kidney function
Creatinine—mg/dl
0.9 (0.8–1.1)
6.3 (3.7–8.8)
5.7 (3.0–7.3)
9.7 (7.5–11.5)
3.4 (1.7–5.0)
eGFR—ml/min
73 (61–87)
9 (6–16)
10 (6–20)
5 (4–8)
15 (8–37)
Hemodialysis—n (%)
0 (0)
83 (75)
18 (60)
85 (100)
8 (36)
HD duration—months
0 (0–0)
26 (1–69)
3 (0–30)
56 (28–100)
0 (0–0.3)
Albuminuria—mg/l
9 (5–16)
644 (327–2110)
2070 (337–3290)
470 (261–1587)
556 (189–1308)
Retinopathy (DR)—n (%)
No DR
107 (82)
1 (0)
6 (20)
—
—
NPDR
23 (18)
68 (63)
11 (37)
—
—
Proliferative DR
—
17 (16)
4 (13)
—
—
Maculopathy
—
8 (7)
3 (10)
—
—
Laser therapy
—
13 (12)
3 (10)
—
—
Polyneuropathy—n (%)
54 (42)
56 (52)
17 (57)
—
—
History—n (%)
Coronary heart disease
42 (32)
74 (69)
11 (37)
24 (30)
6 (22)
Cardiovascular event
20 (15)
42 (39)
7 (23)
14 (18)
5 (23)
Arterial occlusive disease
24 (18)
56 (52)
11 (37)
17 (21)
3 (14)
Stroke
19 (15)
28 (26)
6 (20)
8 (10)
2 (9)
Statin
86 (66)
79 (73)
19 (63)
28 (35)
10 (45)
Homozygous CTG5—n (%)
47 (36)
41 (38)
5 (17)
32 (40)
7 (32)
Patients on hemodialysis only. Categorical data are represented as numbers (%) and continuous data as median with corresponding 25th and 75th percentiles (IQR). AHM: antihypertensive medication; eGFR: estimated glomerular filtration rate; HD: hemodialysis; DR: diabetic retinopathy; NPDR: nonproliferative diabetic retinopathy.
