Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries
Hmox1 deficiency sensitizes mice to diabetic nephropathy development. Body weight (a), fasted blood glycemia (b), microalbuminuria (c), and blood urea nitrogen (BUN) (d) in 20-week-old WT, Hmox1+/−, WT diabetic, and Hmox1+/− diabetic mice. n = 10 to 12 mice. and indicate the statistical significance between Hmox1+/− versus respective WT, that is, Hmox+/− DM versus WT DM and Hmox+/− control versus WT control. #, ##, and ### indicate the statistical significance between the same genotype versus respective control, that is, Hmox+/− DM versus Hmox+/− control, and WT DM versus WT control. and # indicate ; and ## indicate .