Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries

Figure 1

Hmox1 deficiency sensitizes mice to diabetic nephropathy development. Body weight (a), fasted blood glycemia (b), microalbuminuria (c), and blood urea nitrogen (BUN) (d) in 20-week-old WT, Hmox1^+/−, WT diabetic, and Hmox1^+/− diabetic mice. n = 10 to 12 mice. and indicate the statistical significance between Hmox1^+/− versus respective WT, that is, Hmox^+/− DM versus WT DM and Hmox^+/− control versus WT control. #, ##, and ### indicate the statistical significance between the same genotype versus respective control, that is, Hmox^+/− DM versus Hmox^+/− control, and WT DM versus WT control. and # indicate ; and ## indicate .

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