Research Article
Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF-β1 in Renal Tubular Epithelial NRK-52E Cells via Inhibiting Egr-1
Figure 4
TGF-β1-induced EMT reversed by siEgr-1 in NRK-52E cells. NRK-52E cells were transfected by siEgr-1 before TGF-β1 treatment. (a, b) The mRNA (a) and protein (b) expressions of Egr-1. (c–e) The mRNA expressions of E-cadherin, α-SMA, and FN. (f) The protein expression of Egr-1. (g–j) The protein expressions of E-cadherin, α-SMA, and FN. Values are shown as mean ± SD. for each group. , , and versus NC group. and versus (NC + TGF-β1) group.
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