Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A Case-Control Study
Table 3
Distribution of SNP genotype frequencies in CAD-positive and control groups in recessive inheritance mode.
SNPs
CAD-pos. (%)
Controls (%)
95% CI
95% CIa
rs761387
CC
13 (3.3)
6 (2.8)
1.200
0.450–3.203
0.716
1.123
0.295–4.283
0.865
TX
381 (96.7)
211 (97.2)
1
1
rs2268635
AA
40 (10.2)
20 (9.2)
1.113
0.633–1.957
0.710
1.070
0.499–2.295
0.862
GX
354 (89.8)
197 (90.8)
1
1
rs7769547
AA
84 (21.3)
56 (25.8)
0.779
0.528–1.148
0.207
0.851
0.500–1.447
0.551
GX
310 (78.7)
161 (74.2)
1
1
rs910162
AA
83 (21.1)
55 (25.3)
0.786
0.532–1.161
0.226
0.847
0.497–1.446
0.544
TX
311 (78.9)
162 (74.7)
1
1
rs3765468
AA
14 (3.6)
6 (2.8)
1.296
0.491–3.421
0.600
1.249
0.333–4.682
0.742
GX
380 (96.4)
211 (97.2)
1
1
rs3765467
AA
20 (5.1)
9 (4.1)
1.236
0.553–2.764
0.605
2.662
0.588–12.04
0.204
GX
374 (94.9)
208 (95.9)
1
1
rs3765466
TT
123 (31.2)
74 (34.1)
0.877
0.617–1.248
0.466
1.130
0.691–1.848
0.627
AX
271 (68.8)
143 (65.9)
1
1
rs10305456
TT
1 (0.3)
1 (0.5)
0.550
0.034–8.831
1.000
/a
/
/
AX
393 (99.7)
216 (99.5)
1
1
rs10305518
GG
11 (2.8)
5 (2.3)
1.218
0.418–3.551
0.718
1.044
0.267–4.083
0.950
TX
383 (97.2)
212 (97.7)
1
1
rs1820
AA
4 (1)
0 (0)
0.990
0.980–1.000
0.303
/
/
0.999
TX
390 (99)
217 (100)
1
1
rs4714210
GG
28 (7.1)
32 (14.7)
0.442
0.258–0.757
0.002
0.440
0.225–0.863
0.017
AX
366 (92.9)
185 (85.3)
1
CAD: coronary artery disease; OR: odds ratio; CI: confidence interval. ,, and represent ,, and after adjustment for gender, age, BMI, smoking status, hyperlipidemia history, hypertension history, and diabetic duration. , 95% CI, and values were compared using chi-square analysis. , 95% CIa, and were assessed using multiple logistic regression analysis. ,, or could not be acquired because allele frequencies were too small.