Research Article

Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A Case-Control Study

Table 3

Distribution of SNP genotype frequencies in CAD-positive and control groups in recessive inheritance mode.

SNPsCAD-pos.
(%)
Controls
(%)
95% CI95% CIa

rs761387
 CC13 (3.3)6 (2.8)1.2000.450–3.2030.7161.1230.295–4.2830.865
 TX381 (96.7)211 (97.2)11
rs2268635
 AA40 (10.2)20 (9.2)1.1130.633–1.9570.7101.0700.499–2.2950.862
 GX354 (89.8)197 (90.8)11
rs7769547
 AA84 (21.3)56 (25.8)0.7790.528–1.1480.2070.8510.500–1.4470.551
 GX310 (78.7)161 (74.2)11
rs910162
 AA83 (21.1)55 (25.3)0.7860.532–1.1610.2260.8470.497–1.4460.544
 TX311 (78.9)162 (74.7)11
rs3765468
 AA14 (3.6)6 (2.8)1.2960.491–3.4210.6001.2490.333–4.6820.742
 GX380 (96.4)211 (97.2)11
rs3765467
 AA20 (5.1)9 (4.1)1.2360.553–2.7640.6052.6620.588–12.040.204
 GX374 (94.9)208 (95.9)11
rs3765466
 TT123 (31.2)74 (34.1)0.8770.617–1.2480.4661.1300.691–1.8480.627
 AX271 (68.8)143 (65.9)11
rs10305456
 TT1 (0.3)1 (0.5)0.5500.034–8.8311.000/a//
 AX393 (99.7)216 (99.5)11
rs10305518
 GG11 (2.8)5 (2.3)1.2180.418–3.5510.7181.0440.267–4.0830.950
 TX383 (97.2)212 (97.7)11
rs1820
 AA4 (1)0 (0)0.9900.980–1.0000.303//0.999
 TX390 (99)217 (100)11
rs4714210
 GG28 (7.1)32 (14.7)0.4420.258–0.7570.0020.4400.225–0.8630.017
 AX366 (92.9)185 (85.3)1

CAD: coronary artery disease; OR: odds ratio; CI: confidence interval. , , and represent , , and after adjustment for gender, age, BMI, smoking status, hyperlipidemia history, hypertension history, and diabetic duration. , 95% CI, and values were compared using chi-square analysis. , 95% CIa, and were assessed using multiple logistic regression analysis. , , or could not be acquired because allele frequencies were too small.