Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility

Table 4

Association of five single nucleotide polymorphisms with type 1 diabetes susceptibility in all subjects.

Gene	SNP	Model	OR (95% CI)	value
PD-1	rs2227981	ADD	1.05 (0.64 ~ 1.72)	0.846
		DOM	0.98 (0.52 ~ 1.84)	0.941
		REC	1.45 (0.41 ~ 5.12)	0.563
	rs34819629	ADD	0.74 (0.48 ~ 1.13)	0.163
		DOM	0.62 (0.30 ~ 1.27)	0.190
		REC	0.70 (0.34 ~ 1.43)	0.326
PD-L1	rs4143815	ADD	0.50 (0.31 ~ 0.79)	0.003^∗
		DOM	0.31 (0.13 ~ 0.77)	0.012^∗
		REC	0.46 (0.23 ~ 0.92)	0.028^∗
	rs2297136	ADD	0.83 (0.48 ~ 1.43)	0.504
		DOM	0.76 (0.39 ~ 1.48)	0.421
		REC	1.00 (0.21 ~ 4.76)	0.995
	rs2297137	ADD	0.82 (0.53 ~ 1.28)	0.388
		DOM	0.61 (0.29 ~ 1.30)	0.203
		REC	0.97 (0.46 ~ 2.05)	0.930

ADD: additive model; DOM: dominant model; REC: recessive model; additive model: comparing the minor allele with major allele subjects; dominant model: comparing carriers of the minor allele with the major homozygous subjects; recessive model: comparing carriers of the major allele with the minor homozygous subjects.