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Journal of Diabetes Research
Volume 2018 (2018), Article ID 2320737, 8 pages
https://doi.org/10.1155/2018/2320737
Research Article

Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana

1Department of Physiology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
2Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
3Department of Chemical Pathology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
4Department of Medical Biochemistry, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana

Correspondence should be addressed to Kwame Yeboah; moc.liamg@yknivlem

Received 24 July 2017; Revised 30 November 2017; Accepted 12 December 2017; Published 31 January 2018

Academic Editor: Laurent Crenier

Copyright © 2018 Kwame Yeboah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation. Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes. We investigated the association between PSN and arterial stiffness, measured as aortic pulse wave velocity (PWVao) and cardio-ankle vascular index (CAVI). Method. In a case-control design, arterial stiffness was measured in 240 diabetes patients and 110 nondiabetic control. Large-fibre nerve function was assessed by vibration perception threshold (VPT) using a neurothesiometer. PSN was defined as the VPT > 97.5th percentile from age- and gender-adjusted models in nondiabetic controls. Results. The overall prevalence of PSN was 16.6% in the entire study participants. Compared to non-PSN participants, PSN patients had higher levels of PWVao (9.5 ± 1.7 versus 8.7 ± 1.2 m/s, ) and CAVI (8.4 ± 1.3 versus 7.6 ± 1.1, ). In multiple regression models, VPT was associated with PWVao (, ) and CAVI (, ). PSN patients had increased odds of CAVI (OR = 1.51 (1.02–2.4), ), but not PWVao (OR = 1.25 (0.91–1.71), ). Conclusion. PWVao and CAVI were associated with VPT and PSN in diabetes patients in Ghana. Patients having PSN have increased odds of CAVI, independent of other conventional risk factors.