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Journal of Diabetes Research
Volume 2018 (2018), Article ID 2786470, 6 pages
https://doi.org/10.1155/2018/2786470
Research Article

Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients

1Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China
2Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China
3Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China
4Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Correspondence should be addressed to Yongtong Cao; moc.anis@29gnotgnoyoac and Ping Li; moc.361@5768pl

Received 3 August 2017; Accepted 11 October 2017; Published 5 February 2018

Academic Editor: Janet H. Southerland

Copyright © 2018 Liang Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Xu, L. Wang, J. He et al., “Prevalence and control of diabetes in Chinese adults,” Journal of the American Medical Association, vol. 310, no. 9, pp. 948–959, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Remuzzi, A. Schieppati, and P. Ruggenenti, “Clinical practice. Nephropathy in patients with type 2 diabetes,” New England Journal of Medicine, vol. 346, no. 15, pp. 1145–1151, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. L. H. Canani, F. Gerchman, and J. L. Gross, “Familial clustering of diabetic nephropathy in Brazilian type 2 diabetic patients,” Diabetes, vol. 48, no. 4, pp. 909–913, 1999. View at Publisher · View at Google Scholar
  4. R. Skrunes, E. Svarstad, A. V. Reisaeter, and B. E. Vikse, “Familial clustering of ESRD in the Norwegian population,” Clinical Journal of the American Society of Nephrology, vol. 9, no. 10, pp. 1692–1700, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. J. D. Imig, “Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases,” American Journal of Physiology-Renal Physiology, vol. 289, no. 3, pp. F496–F503, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. J. D. Imig, “Epoxygenase metabolites: epithelial and vascular actions,” Molecular Biotechnology, vol. 16, no. 3, pp. 233–252, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. R. J. Roman, “P-450 metabolites of arachidonic acid in the control of cardiovascular function,” Physiological Reviews, vol. 82, no. 1, pp. 131–185, 2002. View at Publisher · View at Google Scholar
  8. A. A. Spector and A. W. Norris, “Action of epoxyeicosatrienoic acids on cellular function,” American Journal of Physiology-Cell Physiology, vol. 292, no. 3, pp. C996–C1012, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Yu, F. Xu, L. M. Huse et al., “Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids,” Circulation Research, vol. 87, no. 11, pp. 992–998, 2000. View at Publisher · View at Google Scholar
  10. J. D. Imig, X. Zhao, C. Z. Zaharis et al., “An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension,” Hypertension, vol. 46, no. 4, pp. 975–981, 2005. View at Publisher · View at Google Scholar
  11. J. J. Olearczyk, J. E. Quigley, B. C. Mitchell et al., “Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats,” Clinical Science, vol. 116, no. 1, pp. 61–70, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Xu, N. Li, Y. He et al., “Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors,” Proceedings of the National Academy of Sciences, vol. 103, no. 49, pp. 18733–18738, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. A. Elmarakby, J. Faulkner, M. Al-Shabrawey, M. H. Wang, K. R. Maddipati, and J. D. Imig, “Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 301, no. 5, pp. R1307–R1317, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Manhiani, J. E. Quigley, S. F. Knight et al., “Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension,” American Journal of Physiology-Renal Physiology, vol. 297, no. 3, pp. F740–F748, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. B. D. Przybyla-Zawislak, P. K. Srivastava, J. Vazquez-Matias et al., “Polymorphisms in human soluble epoxide hydrolase,” Molecular Pharmacology, vol. 64, no. 2, pp. 482–490, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. J. P. Lee, S. H. Yang, D. K. Kim et al., “In vivo activity of epoxide hydrolase according to sequence variation affects the progression of human IgA nephropathy,” American Journal of Physiology-Renal Physiology, vol. 300, no. 6, pp. F1283–F1290, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Ohtoshi, H. Kaneto, K. Node et al., “Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients,” Biochemical and Biophysical Research Communications, vol. 331, no. 1, pp. 347–350, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. M. J. Merkel, L. Liu, Z. Cao et al., “Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 298, no. 2, pp. H679–H687, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Guangzhi, X. Renfan, W. Yinna et al., “Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy,” American Journal of Physiology-Endocrinology and Metabolism, vol. 303, no. 5, pp. E563–E575, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Luo, Y. Zhou, H. H. Chang et al., “Glomerular 20-HETE, EETs, and TGF-β1 in diabetic nephropathy,” American Journal of Physiology-Renal Physiology, vol. 296, no. 3, pp. F556–F563, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Sharma, E. T. McCarthy, D. S. Reddy et al., “8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier,” Prostaglandins & Other Lipid Mediators, vol. 89, no. 1-2, pp. 43–51, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Chen, P. Wang, G. Zhao et al., “Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice,” Prostaglandins & Other Lipid Mediators, vol. 96, no. 1–4, pp. 63–71, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. M. J. Landray, D. C. Wheeler, G. Y. Lip et al., “Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study,” American Journal of Kidney Diseases, vol. 43, no. 2, pp. 244–253, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. J. A. Suwaidi, S. Hamasaki, S. T. Higano, R. A. Nishimura, D. R. Holmes, and A. Lerman, “Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction,” Circulation, vol. 101, no. 9, pp. 948–954, 2000. View at Publisher · View at Google Scholar
  25. L. Zhang, H. Ding, J. Yan et al., “Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population,” Pharmacogenetics and Genomics, vol. 18, no. 1, pp. 45–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Liang, J. Yongwei, K. Xiaomu et al., “Synergistic effect of the MTHFR C677T and EPHX2 G860A polymorphism on the increased risk of ischemic stroke in Chinese type 2 diabetic patients,” Journal of Diabetes Research, vol. 2017, Article ID 6216205, 8 pages, 2017. View at Google Scholar
  27. M. Rutter, T. E. Moffitt, and A. Caspi, “Gene-environment interplay and psychopathology: multiple varieties but real effects,” Journal of Child Psychology and Psychiatry, vol. 47, no. 3-4, pp. 226–261, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. K. S. Moshal, D. C. Zeldin, S. D. Sithu et al., “Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-κβ in hyperhomocysteinemia,” Journal of Cellular Physiology, vol. 215, no. 3, pp. 771–781, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Zhang, X. Xie, Y. Chen, B. D. Hammock, W. Kong, and Y. Zhu, “Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo,” Circulation Research, vol. 110, no. 6, pp. 808–817, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Kim, S. P. Yoon, M. L. Toews et al., “Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy,” American Journal of Physiology-Renal Physiology, vol. 308, no. 2, pp. F131–F139, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Zhao, T. Yamamoto, J. W. Newman et al., “Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage,” Journal of the American Society of Nephrology, vol. 15, no. 5, pp. 1244–1253, 2004. View at Google Scholar