Table 4: Association of R287Q with risk of DN in different Hcy-level groups.

Hcy level (umol/L)UnadjustedAdjusteda
GenotypeOR (95% CI)OR (95% CI)

Low: 4.29–10.78
()
Additive0.67 (0.44–1.02)0.0630.67 (0.41–1.10)0.113
Recessive0.42 (0.14–1.27)0.120.18 (0.03–0.98)0.05
Dominant0.65 (0.38–1.11)0.120.74 (0.40–1.38)0.35
Medium:10.79–13.93
()
Additive0.74 (0.49–1.11)0.140.81 (0.51–1.30)0.38
Recessive0.22 (0.05–0.98)0.0470.27 (0.06–1.28)0.10
Dominant0.82 (0.51–1.32)0.410.93 (0.53–1.65)0.81
High:13.94–55.99
()
Additive0.57 (0.38–0.84)0.0050.52 (0.33–0.81)0.004
Recessive0.32 (0.13–0.82)0.020.27 (0.09–0.78)0.015
Dominant0.56 (0.34–0.92)0.020.51 (0.29–0.90)0.019

DN: diabetic nephropathy; Hcy: homocysteine. aAdjusted for age, sex, BMI, duration of diabetes, hypertension, smoking, total cholesterol, and TG levels.