Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats

Table 2

Effect of menhaden oil with or without salsalate on motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, corneal sensitivity, and cornea nerve fiber length in type 2 diabetic Sprague Dawley rats.

Condition	Motor nerve conduction velocity (m/sec)	Sensory nerve conduction velocity (m/sec)	Thermal nociception (sec)	Intraepidermal nerve fiber density (profiles/mm)	Corneal sensitivity (cm)	Cornea nerve fiber length (mm/mm^2)
Control (12)	55.7 ± 2.1	31.9 ± 0.5	11.9 ± 0.3	20.7 ± 0.7	5.77 ± 0.08	9.5 ± 0.5
Diabetic (12)	40.4 ± 1.4^a	26.7 ± 0.6^a	18.4 ± 0.5^a	13.1 ± 0.8^a	4.67 ± 0.22^a	4.9 ± 0.4^a
Diabetic + salsalate (12)	45.0 ± 1.9^a	27.8 ± 0.4^a	16.0 ± 1.0^a	15.9 ± 0.4^a	4.65 ± 0.20^a	6.6 ± 0.5^a
Diabetic + menhaden oil 10% (12)	44.1 ± 1.8^a	27.3 ± 0.6^a	15.2 ± 1.0	14.5 ± 0.9^a	4.88 ± 0.19^a	6.4 ± 0.5^a
Diabetic + menhaden oil 10% + salsalate (12)	51.0 ± 2.0^b	28.7 ± 0.6^a	13.4 ± 1.2^b	16.2 ± 0.06^a	5.03 ± 0.22^a	6.4 ± 0.5^a
Diabetic + menhaden oil 25% (12)	47.2 ± 1.4^a	28.3 ± 0.5^a	12.3 ± 0.9^b	15.6 ± 1.1^a	4.81 ± 0.16^a	8.1 ± 0.4^b
Diabetic + menhaden oil 25% + salsalate (12)	49.2 ± 1.6^b	29.7 ± 0.4^b	11.2 ± 0.7^b	18.9 ± 1.0^b	5.58 ± 0.10^b	8.5 ± 0.7^b
Diabetic + menhaden oil 45% (12)	51.6 ± 1.4^b	30.0 ± 0.4^b	11.3 ± 0.4^b	19.0 ± 1.2^b	5.54 ± 0.13^b	9.1 ± 0.6^b
Diabetic + menhaden oil 45% + salsalate (12)	52.3 ± 1.2^b	30.3 ± 0.5^b	11.2 ± 0.7^b	19.1 ± 0.6^b	5.88 ± 0.06^b	9.4 ± 0.6^b

Data are presented as the . ^a compared to control rats. ^b compared to diabetic rats. Parentheses indicate the number of experimental animals.