Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats

Table 3

Effect of menhaden oil with or without salsalate on log EC 50 for acetylcholine and calcitonin gene-related peptide-induced relaxation of epineurial arterioles of the sciatic nerve in type 2 diabetic Sprague Dawley rats.

Condition	Acetylcholine	Calcitonin gene-related peptide
Control (12)	−6.35 ± 0.11	−9.69 ± 0.04
Diabetic (12)	−4.04 ± 0.20^a	−9.11 ± 0.08^a
Diabetic + salsalate (12)	−5.12 ± 0.27^a	−9.13 ± 0.07^a
Diabetic + menhaden oil 10% (12)	−4.61 ± 0.44^a	−9.11 ± 0.11^a
Diabetic + menhaden oil 10% + salsalate (12)	−6.03 ± 0.36^b	−9.38 ± 0.07
Diabetic + menhaden oil 25% (12)	−5.93 ± 0.34^b	−9.23 ± 0.11
Diabetic + menhaden oil 25% + salsalate (12)	−6.14 ± 0.31^b	−9.58 ± 0.10^b
Diabetic + menhaden oil 45% (12)	−5.93 ± 0.26^b	−9.46 ± 0.11^b
Diabetic + menhaden oil 45% + salsalate (12)	−5.94 ± 0.25^b	−9.56 ± 0.11^b

Data are presented as the . ^a compared to control rats. ^b compared to diabetic rats. Parentheses indicate the number of experimental animals.