Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats
Table 3
Effect of menhaden oil with or without salsalate on log EC 50 for acetylcholine and calcitonin gene-related peptide-induced relaxation of epineurial arterioles of the sciatic nerve in type 2 diabetic Sprague Dawley rats.
Condition
Acetylcholine
Calcitonin gene-related peptide
Control (12)
−6.35 ± 0.11
−9.69 ± 0.04
Diabetic (12)
−4.04 ± 0.20a
−9.11 ± 0.08a
Diabetic + salsalate (12)
−5.12 ± 0.27a
−9.13 ± 0.07a
Diabetic + menhaden oil 10% (12)
−4.61 ± 0.44a
−9.11 ± 0.11a
Diabetic + menhaden oil 10% + salsalate (12)
−6.03 ± 0.36b
−9.38 ± 0.07
Diabetic + menhaden oil 25% (12)
−5.93 ± 0.34b
−9.23 ± 0.11
Diabetic + menhaden oil 25% + salsalate (12)
−6.14 ± 0.31b
−9.58 ± 0.10b
Diabetic + menhaden oil 45% (12)
−5.93 ± 0.26b
−9.46 ± 0.11b
Diabetic + menhaden oil 45% + salsalate (12)
−5.94 ± 0.25b
−9.56 ± 0.11b
Data are presented as the .a compared to control rats. b compared to diabetic rats. Parentheses indicate the number of experimental animals.