Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat

Table 9

Myocyte calcium from the GK rat heart.

Parameter	Age	Control versus GK	Reference
RCa^2+	14–16 w	0.97 versus 1.25 (RU)	[28]
	8–10 w	NSD	[41]
	5–8 m	NSD	[10]
	10 m	NSD	[47]
	10-11 m	NSD	[48]
	17 m	1.32 versus 1.23 RU NSD	[39]
	18 m	1.28 versus 1.31 RU NSD	[50]
TPK	8–10 w	NSD	[41]
	10 m	55.82 versus 66.14 (ms)	[47]
	10-11 m	NSD	[48]
	17 m	91.7 versus 104.3 ms NSD	[39]
	18 m	64.8 versus 66.6 ms NSD	[50]
THALF	8–10 w	183.46 versus 148.32 (ms)	[41]
	10 m	NSD	[47]
	10-11 m	NSD	[48]
	17 m	199.1 versus 199.0 ms NSD	[39]
	18 m	136.2 versus 123.1 ms NSD	[50]
AMP	8–10 w	NSD	[41]
	5–8 m	NSD	[10]
	10 m	0.25 versus 0.31 (RU)	[47]
	10-11 m	NSD	[48]
	17 m	0.30 versus 0.23 (RU)	[39]
	18 m	0.50 versus 0.78 (RU)	[50]
ICaL amplitude	10-11 m	NSD	[48]
ICaL inactivation	10-11 m	NSD	[48]
ICaL restitution	10-11 m	NSD	[48]
MS Ca^2+	17 m	31.9 versus 89.2 (μm/RU)	[39]

RCa²⁺: resting Ca²⁺; TPK: time to peak Ca²⁺ transient; THALF: time to half decay of the Ca²⁺ transient; AMP: amplitude of the Ca²⁺ transient; ICaL: L-type Ca²⁺ current; MSCa²⁺: myofilament sensitivity to Ca²⁺; NSD: no significant difference. Significant difference.