MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy

<div>Developed renal fibrosis was accompanied by decreased autophagy in DN rats. (a) Representative photograph of histological changes and immunohistochemical staining for Col IV protein expression analysis of renal tissues in NC group and DN group. Figures were shown at ×200 magnification. For (b) and (c), Western blot assay was performed to detect the expression of Col IV, <i>α</i>-SMA, LC3-I, and LC3-II in renal tissues in NC group and DN group. 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Journal of Diabetes Research

fig1

Figure 1

Figure 1: MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy 