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Journal of Diabetes Research
Volume 2018, Article ID 4783093, 8 pages
Research Article

The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana

1Komfo Anokye Teaching Hospital, Kumasi, Ghana
2Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Correspondence should be addressed to Osei Sarfo-Kantanka; moc.liamg@12aknatnakofraso

Received 5 July 2017; Revised 14 October 2017; Accepted 30 October 2017; Published 1 February 2018

Academic Editor: Eusebio Chiefari

Copyright © 2018 Osei Sarfo-Kantanka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations. Methods. This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk scores. Risks were categorised as low (<10%), intermediate (10–19%), and high (≥20%). Associations between metabolic risk factors, thyroid dysfunction, and CHD risk were measured using Spearman’s partial correlation analysis while controlling for age and gender. Differences were considered statistically significant at . Results. 780 T2DM patients (57.7% females), mean ± SD age of 57.4 ± 9.4 was analysed. The median (IQR) 10-year CHD score estimated using the Framingham and UKPDS risk engines for males and females was 12 (8–20), 9.4 (5.7–13.4), and 3 (1–6), 5.8 (3.4–9.6), , respectively. Positive correlation was found between CHD risk and HbA1c, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, and thyroid stimulating hormone. Conclusion. The presence of thyroid dysfunction significantly increased the CHD risk associated with T2DM patients in Ghana.