Research Article

The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana

Table 1

Demographic and clinical characteristics of 780 T2DM participants enrolled for the study.

Test parametersTotalMaleFemale value

Number (%)780 (100)330 (42.3)450 (57.7)
Age, mean ± SD57.4 ± 9.457.8 ± 9.557.3 ± 9.30.65
Age at diagnosis, median (IQR)50 (43–56)51 (43–60)50 (43–78)0.08
Duration of diabetes, mean ± SD9.8 ± 5.69.9 ± 3.29.6 ± 8.90.09
Body mass index (kg/m), median (IQR)27.5 (24.8–30.9)27.0 (24–30.3)27.9 (25.1–31.5)0.04
General obesity (%)262 (33.6)92 (27.9)170 (37.8)0.04
Waist circumference, cm, median (IQR)97 (87–105)94 (84–101)98 (90–106)<0.001
Central obesity, n (%)582 (74.6)156 (47.3)426 (94.7)<0.001
Fasting blood glucose, median (IQR)8.8 (6.7–12.6)8.6 (6 .7–12.2)9.1 (6.8–13.5)0.4
Hba1c (%), median (IQR)8.1 (6.8–9.6)8.1 (6.6–9.8)8.1 (6.9–9.6)0.92
Abnormal glycemic control (>7%)716 (66.2)220 (66.7)286 (63.6)0.85
Total cholesterol mmol/L, median (IQR)5.0 (4.1–6.0)5 (4.2–5.9)5 (4–6.1)0.63
Hypercholesterolemia, n (%)400 (51.3)164 (49.7)236 (52.4)0.15
Triglycerides (mmol/L), median (IQR)1.2 (0.9–1.6)1.16 (0.85–1.6)1.24 (0.94–1.57)0.22
Hypertriglyceridemia, n (%)170 (21.8)66 (20.0)104 (23.1)0.44
LDL-C, median (IQR)3.2 (2.1–3.9)3.1 (2.2–3.8)3.2 (2 .1–4.0)0.92
High LDL, n (%)470 (60.3)186 (56.4)284 (63.1)0.18
HDL-C, median (IQR)1.2 (1–1.5)1.1 (1–1.4)1.2 (1.0–1.5)0.2
Low HDL-C, n (%)54 (6.9)32 (9.6)22 (4.9)0.007
Dyslipidemia, n (%)462 (59.2)196 (59.4)266 (59.1)0.12
Systolic blood pressure, median (IQR)140 (130–150)140 (129–150)140 (130–150)0.43
Diastolic blood pressure, median (IQR)80 (70–90)80 (70–90)80 (80–90)0.01
Hypertension, n (%)602 (77.9)272 (82.4)330 (73.3)0.03
Alcohol, n (%)234 (30.0)200 (60.6)34 (7.6)<0.001
Current smokers, n (%)58 (7.4)56 (17.0)2 (0.4)<0.001
Framingham CHD risk, %, median (IQR)6 (2–12)12 (8–20)3 (1–6)<0.001
UKPDS CHD risk score, median (IQR)4 (0.4–7)9.4(5.7–13.4)5.8 (3.4–9.6)<0.001
Subclinical hypothyroidism64 (8.2)14 (4.2)50 (11.1)0.02
Subclinical hyperthyroidism22 (2.8)14 (4.2)8 (1.8)<0.001
Hypothyroidism12 (1.6)2 (0.6)10 (2.2)0.08
Hyperthyroidism4 (0.5)2 (0.6)2 (0.4)0.21
Euthyroidism678 (86.9)298 (90.3)380 (84.4)0.02

CHD: coronary heart disease; HbA1c: glycated hemoglobin; HDL-C: high-density lipoprotein cholesterol; IQR: interquartile range; LDL-C: low-density lipoprotein cholesterol; UKPDS: United Kingdom Prospective Diabetes Study; SD: standard deviation. statistically significant.