Impact of Metabolic Syndrome Factors on Testosterone and SHBG in Type 2 Diabetes Mellitus and Metabolic Syndrome
Table 4
Comparing of free and total testosterone and SHBG among different groups using ANOVA and general linear model with univariate analysis (ANCOVA).
ANOVA
value
Normal
MetS
T2DM without MetS
T2DM with MetS
ANOVA
MetS against normal
T2DM without MetS against normal
T2DM with MetS against normal
Testosterone (ng/ml)
6.1 (5.5-6.8)
4.1 (3.7–4.7)
5.4 (4.8–6.2)
5.1 (4.4-5.9)
0.0002
8.6 × 10−5
0.5
0.15
SHBG (nmol/l)
40 (36–44)
29 (25–33)
32 (27–38)
33 (29–38)
0.009
0.004
0.11
0.2
Free testosterone (pmol/l)
420 (384–457)
326 (281–372)
415 (365–468)
383 (338–430)
0.01
0.015
0.999
0.66
ANCOVA
ANCOVA
Free testosterone®
361 (310–419)
348 (303–400)
377 (334–425)
400 (352–454)
0.35
0.77
0.60
0.37
Testosterone
5.8 (5.3–6.4)
4.8 (4.2–5.3)
5.8 (5.3–6.3)
5.5 (5.0–6.0)
0.017
0.005
0.84
0.28
Testosterone
5.4 (4.8–6.1)
5.1 (4.5–5.8)
5.6 (5.1–6.1)
5.8 (5.2–6.3)
0.372
0.58
0.67
0.544
SHBG
40 (34–46)
28 (24–33)
37 (32–41)
37 (32–43)
0.002
0.0003
0.41
0.56
SHBG
38 (33–42)
34 (30–38)
35 (31–38)
36 (32–41)
0.46
0.15
0.39
0.70
The results are presented as means and 95% confidence interval; ®general linear model adjusted for waist; general linear model adjusted for SHBG; general linear model adjusted for SHBG and waist; general linear model adjusted for FBG, TG, and age; general linear model adjusted for FBG, TG, age, and testosterone.
