Association between MYH9 and APOL1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population

Table 3

Genetic model analyses of the association between the SNPs and DKD with adjustment for age and gender.

	Genetic models	Genotypes	DKD	DM	Without adjustment		With adjustment
					OR (95% CI)	P	OR (95% CI)	P
rs3752462	Additive	TT	150 (49.5%)	227 (62.4%)	1^#	0.004	1^#	0.005
		TC	128 (42.2%)	115 (31.6%)	1.684 (1.216–2.332)		1.649 (1.187–2.290)
		CC	25 (8.3%)	22 (6.0%)	1.720 (0.935–3.162)		1.817 (0.980–3.367)
	Dominant	TT	150 (49.5%)	227 (62.4%)	1^#	0.001^,∆	1^#	0.001^,∆
		TC + CC	153 (50.5%)	137 (37.6%)	1.690 (1.240–2.303)		1.675 (1.225–2.289)
	Recessive	TT + TC	278 (91.8%)	342 (94.0%)	1^#	0.269	1^#	0.193
		CC	25 (8.2%)	22 (6.0%)	1.398 (0.772–2.533)		1.493 (0.817–2.728)
rs136161	Additive	CC	180 (59.4%)	213 (58.5%)	1^#	0.944	1^#	0.901
		CG	104 (34.3%)	126 (34.6%)	0.977 (0.704–1.354)		1.011 (0.726–1.407)
		GG	19 (6.3%)	25 (6.9%)	0.899 (0.480–1.686)		0.869 (0.460–1.644)
	Dominant	CC	180 (59.4%)	213 (58.5%)	1^#	0.816	1^#	0.933
		CG + GG	123 (40.6%)	151 (41.5%)	0.964 (0.707–1.314)		0.987 (0.721–1.350)
	Recessive	CC + CG	284 (93.7%)	339 (93.1%)	1^#	0.757	1^#	0.652
		GG	19 (6.3%)	25 (6.9%)	0.907 (0.489–1.681)		0.866 (0.463–1.618)

Abbreviations: ORs, odds ratios; CI, confidence interval. ^#Reference category (odds ratio, 1.0); value < 0.05; ∆ indicates statistical significance by Holm-Bonferroni correction.