Markers of Anemia in Children with Type 1 Diabetes

Table 1

Age, clinical parameters related to type 1 diabetes (T1D), complete blood count and serum parameters results in all patients with T1D and in the control group. Parameters are expressed as mean value and its 95% confidence interval.

		T1D ()	Controls ()
Clinical parameters	Age (yrs)	12.9 (12.1, 13.8)	13.1 (12.0, 14.3)
	Age at T1D diagnosis (yrs)	8.7 (7.9, 9.5)
	T1D duration (yrs)	4.2 (3.5, 4.9)
	HbA1c (%)	7.34 (7.02, 7.65)
Complete blood count	RBC (10^6/μl)	4.72 (4.64, 4.79)	4.76 (4.64, 4.89)
	MCV (fl)	86.5 (85.7, 87.3)	85.5 (84.2, 86.8)
	MCHC (g/dl)	33.8 (33.7, 34.0)	34.0 (33.7, 34.3)
	Hemoglobin (g/dl)	13.79 (13.58, 13.99)	13.83 (13.46, 14.21)
	Hematocrit (%)	40.8 (40.0, 41.4)	40.7 (39.7, 41.7)
	RDW (%)	13.6 (13.3, 13.8)	12.6 (12.4, 12.9)
Serum parameters	Iron (μmol/l)	17.34 (16.19, 18.49)	16.40 (14.19, 18.60)
	TIBC (μmol/l)	59.09 (57.51, 60.67)	68.15 (65.29, 71.02)
	Ferritin (μg/l)	48.51 (41.93, 55.08)	45.87 (35.21, 56.53)
	Transferrin (g/l)	3.01 (2.47, 3.56)	3.01 (2.83, 3.19)
	Vitamin B12 (pg/ml)	459 (419, 500)	397 (356, 437)
	Hepcidin (ng/ml)	0.25 (0.20, 0.29)	0.12 (0.10, 0.14)

T1D: type 1 diabetes, HbA1c: glycated hemoglobin A1c, RBC: red blood cells, MCV: mean corpuscular volume, MCHC: mean corpuscular hemoglobin concentration, RDW: red blood cell distribution width, TIBC: total iron-binding capacity. Significant difference between T1D and controls (RDW ; vitamin B12 ; hepcidin ; TIBC ).