Haptoglobin Genotype Is a Determinant of Hemoglobin Adducts and Vitamin E Content in HDL

Figure 4

The effect of Hp genotypes on the cholesterol efflux of oxidized HDL. Hb-Hp1-1 or Hb-Hp 2-2 complexes were incubated with the same HDL preparation in the presence of H₂O₂ (1 : 10 molar excess) for 1 hour. After incubation, the samples were added to macrophages and the efflux of (³H) cholesterol from macrophages was measured ( indicates the value < 0.001 (t-test) comparing Hb/Hp 1-1 versus Hb/Hp 2-2).