Journal of Diabetes Research / 2018 / Article / Tab 2

Review Article

Application of Metabolomics to Study Effects of Bariatric Surgery

Table 2

The detailed results from the pathway analysis.

Pathway nameFDRImpact

Aminoacyl-tRNA biosynthesis0.16902
Glycine, serine, and threonine metabolism0.48394
Nitrogen metabolism
Phenylalanine metabolism0.011770.20468
Cysteine and methionine metabolism0.0152990.54182
Citrate cycle (TCA cycle)0.00148740.0154530.28353
Taurine and hypotaurine metabolism0.00148740.0154530.46583
Valine, leucine, and isoleucine biosyntheses0.00154670.0154530.12084
Propanoate metabolism0.00173840.0154530.07344
Nicotinate and nicotinamide metabolism0.00207640.0166110.06485
Alanine, aspartate, and glutamate metabolism0.00412180.0299770.53182
Arginine and proline metabolism0.00451570.0301040.4641
Synthesis and degradation of ketone bodies0.00514670.0316720.7
Pyrimidine metabolism0.00576440.0329390.22308
Methane metabolism0.00627920.0334890.18217
Glutathione metabolism0.0117330.0586660.34321
Glyoxylate and dicarboxylate metabolism0.0167070.0775240.1897
Pyruvate metabolism0.0177330.0775240.42654
Purine metabolism0.0184120.0775240.30417
Pantothenate and CoA biosyntheses0.0312740.12510.0
D-Glutamine and D-glutamate metabolism0.0330630.125960.35294
Valine, leucine, and isoleucine degradation0.0482330.167770.0835
Butanoate metabolism0.0482330.167770.18589
Glycolysis or gluconeogenesis0.0530560.176850.09576
Linoleic acid metabolism0.0748810.239620.65625
Cyanoamino acid metabolism0.0877760.270080.0
Primary bile acid biosynthesis0.0919950.272580.08068
D-Arginine and D-ornithine metabolism0.0964270.275510.0
Sulfur metabolism0.116090.313150.06614
Glycerophospholipid metabolism0.117430.313150.17061
Galactose metabolism0.137570.355030.24385
Vitamin B6 metabolism0.164540.398890.24174
Glycerolipid metabolism0.164540.398890.27975
Thiamine metabolism0.216330.509010.0
Fatty acid biosynthesis0.230920.521230.0
Sphingolipid metabolism0.234550.521230.04244
Tyrosine metabolism0.247720.53560.12506
Phenylalanine, tyrosine, and tryptophan biosyntheses0.271740.572080.008
beta-Alanine metabolism0.290580.596050.0
alpha-Linolenic acid metabolism0.309510.619020.20335
Histidine metabolism0.343480.670210.21313
Selenoamino acid metabolism0.441980.841860.00321
Biotin metabolism0.53610.99740.0
Ascorbate and aldarate metabolism0.593251.00.13047
Arachidonic acid metabolism0.609981.00.2595
Lysine degradation0.623331.00.14675
Glycosylphosphatidylinositol- (GPI-) anchor biosynthesis0.624011.00.0
Tryptophan metabolism0.624321.00.24863
Pentose phosphate pathway0.645911.00.0
Lysine biosynthesis0.645911.00.09993
Starch and sucrose metabolism0.665551.00.0765
Pentose and glucuronate interconversions0.704261.00.02401
Porphyrin and chlorophyll metabolism0.713741.00.05249
Inositol phosphate metabolism0.750541.00.18387
Riboflavin metabolism0.769961.00.0
Caffeine metabolism0.769961.00.0305
Fatty acid elongation in mitochondria0.849211.00.0
Terpenoid backbone biosynthesis0.901261.00.0
Ubiquinone and other terpenoid-quinone biosyntheses0.920131.00.0
Amino sugar and nucleotide sugar metabolism0.94391.00.0
Fructose and mannose metabolism0.965911.00.0
Steroid hormone biosynthesis0.968781.00.10049
Fatty acid metabolism0.970431.00.02959

Raw is the original value calculated from the enrichment analysis; the FDR is the value adjusted using false discovery rate; the Impact is the pathway impact value calculated from pathway topology analysis.