Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Figure 2

Effects of intraperitoneal injection of saline over 4 days on daily food intake (a) and body weight changes (b) in mice treated with or without PCPA (500 mg/kg) for 3 days. Effects of intraperitoneal injection of liraglutide (100 μg/kg) over 4 days on daily food intake (c) and body weight changes (d) in mice treated with or without PCPA (500 mg/kg) for 3 days. Basal body weight of mice without PCPA was 22.3 ± 0.2 g, and basal body weight of mice treated with PCPA was 20.3 ± 0.6 g. Open triangle: mice treated with saline following treatment with 1% Tween saline alone for 3 days; closed triangle: mice treated with saline following treatment with PCPA for 3 days; open circle: mice treated with liraglutide following treatment with 1% Tween saline alone for 3 days; filled circle: mice treated with liraglutide following treatment with PCPA for 3 days. Data are presented as the mean values ± SEM (/group of animals).

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