Genetic Variability of the Glucose-Dependent Insulinotropic Peptide Gene Is Involved in the Premature Coronary Artery Disease in a Chinese Population with Type 2 Diabetes

Table 4

The association of SNPs with CAD risk in additive inheritance mode.

Gene	SNPs genotype	CAD positive n (%)	CAD negative n (%)	OR (95% CI)		OR (95% CI)
GIP	rs2291725
	C/C	187 (48.6)	102 (37.5)
	C/T	152 (39.5)	140 (51.5)	0.592 (0.424–0.826)	0.002	0.603 (0.392–0.930)	0.022
	T/T	46 (11.9)	30 (11.0)	0.836 (0.498–1.406)	0.500	0.709 (0.502–1.001)	0.051
	rs8078510
	G/G	281 (73.2)	174 (64.7)
	G/A	96 (25.0)	90 (33.5)	0.660 (0.468–0.932)	0.018	0.567 (0.364–0.883)	0.012
	A/A	7 (1.8)	5 (1.8)	0.867 (0.271–2.774)	0.810	1.065 (0.427–2.653)	0.893

OR, 95% CI, and p were calculated by logistic regression analysis after adjustment for other known CAD risk factors (age, BMI, smoking status, dyslipidemia history, hypertension history, and diabetic duration).