Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs

Table 2

Study timeline. Varying metabolic assessments performed at time points W(−3) to W(30). At W(−3), we performed IVGTT on pigs. At W18, we performed IVGTT and subcutaneous fat biopsies on all pigs. At W30, we performed IVGTT, extra- and intra-abdominal fat biopsies, and full-body computed tomography scans on all pigs.

			W(−3)	W0	W18	W30
Age in weeks	0	29	35	38	56	68
Diet	Chow			HFFD
Intervention		Castration			Drug trial (MLDL1278A)	CT-scans
			Fasting lipids ()		Fasting lipids ()	Fasting lipids ()
			IVGTT ()		IVGTT ()	IVGTT ()
					Blood pressures	Blood pressures
					Subcutaneous AT biopsies	Subcutaneous AT biopsies
						Necropsy