Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs
Table 3
Characteristics of metabolic parameters in the FBM pigs.
FBM pig
Obesogenic diet
Ad libitum: 2.0% cholesterol, 22% fat (lard), 18% fructose
Control diet
No control diet
W(−3)
W18
W30
()
Duration
33 weeks
12 weeks
Weight (kg)
25.6
87
112
Fasting glucose (mmol/L)
3.9 (3.7–4.2)
4.1 (3.9–4.3)
Fasting insulin (mU/L)
2.6 (2.2–3.2)
3.1 (2.5–4.4)
HOMA-IR
0.46 (0.36–0.58)
0.57 (0.43–0.86)
Insulin AUC (mU/L × min)
862 (671–1048)
1189 (915–1463)
Glucose AUC (mmol/L × min)
862 (±15)
948 (±17)
Systolic blood pressure (mmHg)
141 (127–150)
131 (113–141)
Diastolic blood pressure (mmHg)
68 (±13)
66 (±14)
Mean blood pressure (mmHg)
93 (86–101)
91 (73–97)
Triglycerides (mmol/L)
0.4 (0.4–0.5)
0.5 (0.4–0.8)
Cholesterol
Total (mmol/L)
4.1 (±0.3)
16 (±1.1)
HDL (mmol/L)
0.7 (±0.1)
2.6 (±0.3)
LDL (mmol/L)
3.1 (2.4–3.8)
14 (11–15)
LDL/HDL ratio
3.9 (2.8–5.7)
5.4 (3.6–7.5)
For detailed statistical information, see supplementary information. Data is presented as mean (±SD) or median (interquartile range) where appropriate; .
