Research Article

The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice

Figure 4

(a) α-Klotho renal expression in nondiabetic and diabetic nephropathy patients. (b) The percentage of the stained area of α-klotho is significantly decreased in the renal tubules of diabetic (DM) biopsies with Hp 2-2 genotype compared with Hp 1-1 diabetic () or with nondiabetic (nonDM) Hp 2-2 genotype (). (c) In chronic kidney disease (CKD) patients with the Hp 2-2 genotype, the renal expression of α-klotho declines with the progression in the CKD stage, and it is exacerbated in the diabetic state.
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