Research Article

Relationship of Hyperglycaemia, Hypoglycaemia, and Glucose Variability to Atherosclerotic Disease in Type 2 Diabetes

Table 1

Baseline demographic and clinical findings of study population.

Patient characteristics ()Values

Age (years)64 (57–68)
Male : female (n (%))89 (73.6) : 32 (26.4)
Diabetes duration (years)3 (2–5)
Smoking (current/ex/nonsmokers) (n (%))22 (18.2)/41 (33.9)/58 (47.9)
Hypertension (n (%))80 (66.1)
Hyperlipidaemia (n (%))87 (71.9)
Ischaemic heart disease (n (%))15 (12.4)
Peripheral arterial disease (n (%))7 (5.8)
Cerebrovascular accident/transient ischaemic attack (n (%))3 (2.5)
Abnormal carotid intima-media thickness (n (%))64 (52.9)
Macrovascular disease (n (%))72 (59.5)
Chronic kidney disease (n (%))9 (7.4)
On metformin (n (%))109 (90.1)
On sulphonylurea (n (%))36 (29.8)
On gliptins (n (%))6 (5)
On insulin (n (%))6 (5)
On angiotensin-converting enzyme inhibitor/on angiotensin receptor blocker (n (%))77 (63.6)
On β-blocker (n (%))22 (18.2)
On calcium channel blocker (n (%))23 (19)
On diuretic (n (%))33 (23.7)
On aspirin (n (%))38 (31.4)
On statin (n (%))81 (66.9)
On fibrate (n (%))7 (5.8)
On allopurinol (n (%))5 (4.1)
Body mass index (kg/m2)31.22 (27.94–34.53)
Body surface area (m2)1.89 ± 0.21
Waist index1.19 ± 0.14
Pulse rate (bpm)68 (61.5–78.5)
Mean systolic pressure (mmHg)144.19 ± 17.82
Mean diastolic pressure (mmHg)84.60 ± 8.76
Pulse pressure (mmHg)61.53 ± 13.66
Mean arterial pressure (mmHg)107 (93–113)
White cell count (×109/L)7.16 (6.26–8.69)
Haemoglobin (g/dL)14.35 (13.33–15.18)
Platelet count (×109/L)240.5 (206–284.75)
Red blood cell distribution width (%)13.1 (12.53–13.7)
Mean platelet volume (fL)10.9 (10.2–11.6)
Estimated glomerular filtration rate (mL/min/1.73 m2)91.22 ± 24.61
Total cholesterol (mmol/L)4.12 (3.55–5.15)
HDL cholesterol (mmol/L)1.24 (1.06–1.51)
LDL cholesterol (mmol/L)2.19 (1.67–3.19)
Non-HDL cholesterol (mmol/L)2.8 (2.26–3.82)
Triglycerides (mmol/L)1.36 (0.97–1.7)
Alkaline phosphatase (mmol/L)69 (55–83.5)
Alanine transaminase (mmol/L)23 (18–32.5)
Uric acid (μmol/L)313.05 ± 79.98
Erythrocyte sedimentation rate (mm 1st hr)10.5 (6–18)
Albumin-creatinine ratio (mg/mmol)7.08 (1–23.34)
Fasting plasma glucose (mmol/L)7.08 (6.11–8.18)
Fructosamine (μmol/L)278 (257–303)
Glycated haemoglobin (%)6.8 (6.3–7.6)

Values are expressed as number (%) of patients, mean ± SD, or median (IQR).