TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes

Figure 6

Diabetes activates Par-4 and inhibits TERT and p-Akt, inducing islet β cell apoptosis. (a) Immunocytochemistry analysis of Par-4 and TERT expression in cytoplasmic and nuclear extracts in each group. (b) Apoptosis was detected via TUNEL staining in each group. (c) Western blots of Par-4, TERT, Akt, and p-Akt expression in each group. (d) Expression of Par-4 (A), TERT (B), Akt (C), and p-Akt (D), apoptosis rates (E), secretion of Par-4 (F), the HOMA- β index (G), and glucose-stimulated insulin secretion (H) in each group. (e) Signal transduction via the Par-4/TERT-Akt pathway to induce islet β cell apoptosis in diabetes. Compared with the N group, . ^#Compared with the D group, .

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