Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model

Table 3

STZ-induced mortality appears to depend on the age of the rat at the time of STZ injection.

Body weight (g)	220–400	220–400	401–500	501–600	501–600	Total
Age (weeks)	6–11	6–11	12–17	18–23	18–23
Rats received single STZ 65 mg/kg i.v.	50	0	29	20	0	99
Rats received single STZ 50 mg/kg i.v.	0	0	0	0	14	14
Rats received double STZ 50 mg/kg i.v. 3 days apart	0	17	0	0	0	17
Total rats injected with STZ	50	17	29	20	14	130
Rats surviving the 1^st week after STZ i.v.	48	17	5	3	0	73
% surviving the 1^st week post injection	96%	100%	17.2%	8.8%	0%	—
Week of mortality after the 1^st week	—	—	9, 12, 21, 21, 25	9, 9, 21	—	—
% surviving to end of study at week 60	96%	100%	0%	0%	0%	—