Research Article

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

Table 1

Target genes, encoded proteins, and description of proteins.

GenesProteinsProtein descriptions

Gap junction proteins
Gja1Cx43Connexin43
Gja5Cx40Connexin40
Gjc1Cx45Connexin45
Gjd3Cx31.9Connexin31.9
Cell membrane transport
Atp1a1Na/K ATPase, α1ATPase, Na+/K+ transporting, alpha 1 polypeptide
Atp1a2Na/K ATPase, α2ATPase, Na+/K+ transporting, alpha 2 polypeptide
Atp1a3Na/K ATPase, α3ATPase, Na+/K+ transporting, alpha 3 polypeptide
Atp1b1Na/K ATPase, β1ATPase, Na+/K+ transporting, beta 1 polypeptide
Atp2b1Na/K ATPase, β2ATPase, Ca++ transporting, plasma membrane 1
Slc8a1NCX1Solute carrier family 8 (sodium/calcium exchanger), member 1
Trpc1TRPC1Transient receptor potential channel 1
Trpc3TRPC3Transient receptor potential channel 3
Trpc6TRPC6Transient receptor potential channel 6
Intercellular Ca2+ transport and Ca2+ regulation
Atp2a2SERCA2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Calm1Calm1Calmodulin 1
Calm3Calm3Calmodulin 3
Casq2Casq2Calsequestrin 2
Itpr1IP3R1Inositol 1,4,5-trisphosphate receptor, type 1
Itpr2IP3R2Inositol 1,4,5-trisphosphate receptor, type 2
Itpr3IP3R3Inositol 1,4,5-trisphosphate receptor, type 3
PlnPLBPhospholamban
Ryr2/RYR2RYR2Ryanodine receptor 2
Ryr3/RYR3RYR3Ryanodine receptor 3
Hyperpolarization-activated cyclic nucleotide-gated channels
Hcn1HCN1Hyperpolarization-activated cyclic nucleotide-gated channel 1
Hcn2HCN2Hyperpolarization-activated cyclic nucleotide-gated channel 2
Hcn3HCN3Hyperpolarization-activated cyclic nucleotide-gated channel 3
Hcn4HCN4Hyperpolarization-activated cyclic nucleotide-gated channel 4
Calcium channels
Cacna1cCav1.2Voltage-dependent, L-type, alpha 1C subunit
Cacna1dCav1.3Voltage-dependent, L-type, alpha 1D subunit
Cacna1gCav3.1Voltage-dependent, T-type, alpha 1G subunit
Cacna1hCav3.2Voltage-dependent, T-type, alpha 1H subunit
Cacna2d1Cavα2δ1Voltage-dependent, alpha 2/delta subunit 1
Cacna2d2Cavα2δ2Voltage-dependent, alpha 2/delta subunit 2
Cacna2d3Cavα2δ3Voltage-dependent, alpha 2/delta subunit 3
Cacnb1Cavβ1Voltage-dependent, beta 1 subunit
Cacnb2Cavβ2Voltage-dependent, beta 2 subunit
Cacnb3Cavβ3Voltage-dependent, beta 3 subunit
Cacng4Cavγ4Voltage-dependent, gamma subunit 4
Cacng7Cavγ7Voltage-dependent, gamma subunit 7
Potassium channels
Kcna1Kv1.1Voltage-gated shaker-related subfamily A, member 1
Kcna2Kv1.2Voltage-gated shaker-related subfamily A, member 2
Kcna3Kv1.3Voltage-gated shaker-related subfamily A, member 3
Kcna4Kv1.4Voltage-gated shaker-related subfamily A, member 4
Kcna5Kv1.5Voltage-gated shaker-related subfamily A, member 5
Kcnb1Kv2.1Voltage-gated shab-related subfamily B, member 1
Kcnd1Kv4.1Voltage-gated shal-related subfamily D, member 1
Kcnd2Kv4.2Voltage-gated shal-related subfamily D, member 2
Kcnd3Kv4.3Voltage-gated shal-related subfamily D, member 3
Kcnh2ERG-1Ether-A-go-go-related protein 1
Kcnip2KChIP2Kv channel interacting protein 2
Kcnj11Kir6.2Inwardly rectifying subfamily J, member 11
Kcnj12Kir2.2Inwardly rectifying subfamily J, member 12
Kcnj14Kir2.4Inwardly rectifying subfamily J, member 14
Kcnj2Kir2.1Inwardly rectifying subfamily J, member 2
Kcnj3Kir3.1Inwardly rectifying subfamily J, member 3
Kcnj5Kir3.4Inwardly rectifying subfamily J, member 5
Kcnj8Kir6.1Inwardly rectifying subfamily J, member 8
Kcnk1TWIK1Two pore domain subfamily K, member 1
Kcnk2TREK1Two pore domain subfamily K, member 2
Kcnk3K2P3.1Two pore domain subfamily K, member 3
Kcnk5K2P5.1Two pore domain subfamily K, member 5
Kcnk6TWIK2Two pore domain subfamily K, member 6
Kcnn1SK1Calcium-activated intermediate/small conductance subfamily N alpha, member 1
Kcnn2SK2Calcium-activated intermediate/small conductance subfamily N alpha, member 2
Kcnn3SK3Calcium-activated intermediate/small conductance subfamily N alpha, member 3
Kcnq1Kv7.1Voltage-gated KQT-like subfamily Q, member 1
Miscellaneous proteins
Abcc8SUR1ATP-binding cassette transporter subfamily C member 8
Abcc9SUR2ATP-binding cassette subfamily C member 9
NppaANPAtrial natriuretic peptide
NppbBNPBrain natriuretic peptide
Pias3KChAPProtein inhibitor of activated STAT3