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Journal of Diabetes Research
Volume 2018, Article ID 8546423, 6 pages
Research Article

Levels of Inflammatory Cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in Aqueous Humour of Patients with Diabetic Retinopathy

1Department of Ophthalmology, ZhuJiang Hospital of Southern Medical University, Guangzhou 510280, China
2Department of Ophthalmology, Guangdong Eye Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
3Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical College, Kunming 650031, China
4Gejiu People’s Hospital, Gejiu 661000, China
5The Second People’s Hospital of Jiangxi, Nanchang 330000, China

Correspondence should be addressed to Ling Yuan; moc.361@1608gnilnauy

Songfu Feng, Honghua Yu, and Ying Yu contributed equally to this work.

Received 20 October 2017; Revised 29 December 2017; Accepted 24 January 2018; Published 4 April 2018

Academic Editor: Pedro M. Geraldes

Copyright © 2018 Songfu Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries either with DR or without DR. All cases were further categorized by the proliferative stages of retinal neovascularization and by the lengths of diabetic history. The levels of inflammatory cytokines including IL-1β, IL-6, IL-8, IL-17, and TNF-α in aqueous humour were tested. Results in this study indicated that these cytokine levels were increased in DR patients and might have a synergistic effect on the pathogenesis of this disease. They were also elevated along with the progression of neovascularization, reflecting the severity of DR. The results also suggested that for diabetic patients, the higher these levels are, the sooner retinal complications might appear. In conclusion, the levels of inflammatory cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in aqueous humour may be associated with the pathogenesis, severity, and prognosis of DR.