Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage

Figure 12

(a) Western blot analysis showed the expression of VEFG, Flk-1, CREB, and PKC in the NC11w, DM11w, DM11w + LR, and DM11w + B groups, including the immunoreactive bands of VEGF (21 kDa), iNOS (130 kDa), eNOS (140 kDa), nNOS (155 kDa), and β-actin (42 kDa). Bar graph showed the semiquantitative data of Western blot analysis of VEGF (a), Flk-1 (b), CREB (c), and PKC (d). (a) VEGF showed an evident increase in the DM11w and DM11w + LR groups compared with the NC11w group. (b–d) Flk-1, CREB, and PKC showed significant increase in the DM11w and DM11w + LR groups compared with the NC11w group, which was attenuated in the DM11w + B group. and .

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