Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Figure 2

SPR abolished myocardial oxidative stress in diabetic rats. (a) Representative immunohistochemical (IHC) micrographs of myocardium tissue from NDC, STZ + NS, and STZ + SPR groups stained with nitrotyrosine. Magnification 20×. (b) Immunohistochemical scores for the IHC staining of myocardium sections. (c, d) Gene expression of Nrf-1 and GCLC for these three groups. , data are shown as . , , and vs. NDC group; and vs. STZ + NS group.

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