Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Figure 5

SPR reduced cardiac inflammation in DCM. (a) Representative immunohistochemical micrographs of cardiac tissue stained with TNF-α and F4/80 for NDC, STZ + NS, and STZ + SPR groups, respectively (original magnification 20×). (b) The IHC scores of heart sections for TNF-α IHC staining. (c) The percentage of positive staining per section for F4/80 IHC staining. (d, e) Gene expression of TNF-α and MCP-1 for these three groups, respectively. , data are shown as . ^∗P<0.05, ^∗∗P<0.01, and ^∗∗∗P<0.001 vs. NDC group; and vs. STZ + NS group.

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