Journal of Diabetes Research / 2018 / Article / Fig 2

Research Article

Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes

Figure 2

GADA titers and GADA subclass distribution in GAD-alum lymph node and subcutaneous treatment. (a) Median values of GADA titers in the lymph node (LN, ) or subcutaneous vaccination (SC, ). (b) Change of the frequency (%) of IgG1, IgG2, IgG3, and IgG4 GADA subclasses. Frequencies were calculated with respect to the combined sum of the AUs of the 4 subclasses in each sample. The median percentage with respect to the total IgG is shown for each respective subclass. (c) GADA subclass relative contribution at baseline, 90, and 180 days for LN and SC groups.

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