Journal of Diabetes Research / 2018 / Article / Fig 4

Research Article

Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes

Figure 4

T cell activation induced by GAD65 in lymph node (LN, , black circles) and subcutaneous (SC, , white circles) GAD-alum patients. (a) Percentage of GAD65-activated CD4+CD25+CD127+ T cells and (b) CD8+CD25+CD127+ T cells. (c) Mean percentage of CD4+CD25+CD127lo/−FOXP3+ (Treg) in resting samples (medium alone) and (d) induced by GAD65 stimulation. (e) Mean percentage of FOXP3loCD45RA nonsuppressor regulatory T cells in resting samples (medium alone) and (f) GAD65-stimulated samples.

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