Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation

Table 3

Core body temperature in light and dark phases at 2 and 8 weeks.

		2 weeks		8 weeks		values (two-way ANOVA)
Male		WT	db/db	WT	db/db	Age	Genotype	Interaction
Time measured (h)
8:00	°C	35.70 ± 0.22	33.93 ± 0.20	36.66 ± 0.21	34.51 ± 0.34	<0.01	<0.01	0.455
20:00	°C	36.38 ± 0.18^NS	34.99 ± 0.21	38.10 ± 0.28	36.60 ± 0.15	<0.01	<0.01	0.795
Female		WT	db/db	WT	db/db	Age	Genotype	Interaction
Time measured (h)
8:00	°C	36.14 ± 0.09	33.89 ± 0.15	36.64 ± 0.13	33.96 ± 0.13	0.051	<0.01	0.126
20:00	°C	37.36 ± 0.11	34.96 ± 0.15	37.90 ± 0.10	35.89 ± 0.28	<0.01	<0.01	0.279

WT: wild type (homozygous wild type in Lepr gene); db/db: leptin receptor deficiency (homozygous mutants in Lepr gene). Values are the mean ± SE. Values were analyzed by two-way ANOVA (interaction, age, and genotype). Values of the respective genotype male or female mice at the same age were analyzed by paired Student’s t-test. NS: not significant; , vs. male or female mice of the respective genotype at the same age at 8:00 h.