Research Article

Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer

Table 1

Clinical characteristics of the study groups.

Entire group ()MV subgroup ()
NPWTST valueNPWTST value

Sex M/F ()42/715/50.3117/28/20.59
Age (year)0.930.06
BMI (kg/m2)0.3827.7 (25.7-30.9)27.3 (25.6-29.1)0.91
Duration of diabetes (year)0.250.23
Insulin treatment Y/N ()48/118/20.2018/19/11.00
Duration of insulin therapy (year)5.0 (1.0-10.0)6.0 (3.0-15.0)0.384.0 (1.0-8.0)10.0 (3.0-13.5)0.10
Daily dose of insulin (unit)50.0 (40.0-70.0)50.0 (30.0-60.0)0.700.96
HbA1c (mmol/mol)51.9 (43.2-58.5)56.3 (43.7-66.7)0.2547.5 (41.0-56.3)48.1 (39.9-60.7)0.96
HbA1c (%)6.9 (6.1-7.5)7.3 (6.2-8.3)0.256.5 (5.9-7.3)6.6 (5.8-7.7)0.96
eGFR (mL/min/1.73 m2)88.0 (63.0-93.0)80.5 (58.0-95.5)0.7487.0 (55.0-92.0)76.0 (53.0-98.0)0.80
Wound area (cm2)10.3 (4.2-18.9)1.3 (0.9-3.4)0.000112.6 (3.8-19.2)1.0 (0.8-1.4)0.001
Duration of the wound (week)12.2 (10.1-23.7)10.3 (4.1-18.0)0.1612.0 (10.1-22.9)10.0 (5.1-24.9)0.30

Data shown as number of cases, (for normally distributed variables) or median and IQR (for nonnormally distributed variables).