Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes

Figure 1

The expressions of PD-L1 and PD-1 on CD4⁺ T cells (marked with CD3⁺CD4⁺) in T2D patients and healthy donors. Peripheral blood mononuclear cells (PBMCs) were isolated from healthy donors () and patients with T2D (). (a) Typical flow cytometry analysis of PD-L1 expression on CD4⁺ T cells (left) and the statistical graph (right) are shown for the T2D patients (, %) and healthy donors (, %). (b) Typical flow cytometry analysis of the PD-1 expression on CD4⁺ T cells (left) and the statistical graph (right) are shown for the T2D patients (, %) and healthy donors (, %). (c) Correlation analysis of the PD-1 expression on CD4⁺ T cells and age, fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), body mass index (BMI), insulin, and diabetes duration. .

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