Research Article

Expression Profiling and Clinical Significance of Plasma MicroRNAs in Diabetic Nephropathy

Table 1

Characteristics of participants.

ParametersNC group
()
DM group
()
DN group
()
DN group
Mic group ()Mac group ()

Gender (male/female)21/1922/1834/3220/1614/16
Age (years)
Duration of diabetes (years)ā€”
FPG (mmol/L)
Blood urea nitrogen (mmol/L)
Serum creatinine (Ī¼mol/L)
Triglyceride (mmol/L)
Total cholesterol (mmol/L)
LDL-C (mmol/L)
HDL-C (mmol/L)
Retinopathy, (%)0 (0.0)16 (40.0)49 (74.2)#23 (63.9)26 (86.7)a
cIMT (cm)ā€”
Hypertension, (%)0 (0.0)15 (37.5)45 (68.2)#18 (50.0)27 (90.0)a
Cardiomegaly, (%)0 (0.0)19 (47.5)48 (72.7)#21 (58.3)27 (56.7)a

NC: normal controls; DM: diabetes mellitus with normoalbuminuria; Mic: diabetic nephropathy with microalbuminuria; Mac: diabetic nephropathy with macroalbuminuria. FPG: fasting plasma glucose; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; cIMT: carotid intima-media thickness. Comparisons were made between groups using the nonparametric Mann-Whitney -test. between DM vs. DN; # between NC vs. DN; a between Mac vs. Mic.