Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy

Figure 6

Disruption of IAP/SHPS-1 association via intraocular injection of an anti-IAP antibody prevented the hyperglycemia-induced increase in vascular permeability. The animals were treated following the protocol for the diabetic retinopathy preventive study described in Materials and Methods. Evans blue permeation from the retinal vasculature was measured after 3 weeks of treatment ( for nondiabetic rats and for each group of diabetic rats with control antibody or anti-IAP antibody) following the procedure described in Materials and Methods. indicates the significant difference between two treatments. , NS indicates no significant difference between two treatments.