Polymorphisms in NLRP1 Gene Are Associated with Type 1 Diabetes

Table 4

Models proposed for NLRP1 polymorphisms between cases and controls in the Chinese Han population.

SNP	Minor allele	Genetic model
		Dominant model			Recessive model			Overdominant model			Additive model
		OR (95% CI)			OR (95% CI)			OR (95% CI)			OR (95% CI)
rs11651270	C	0.648 (0.503-0.834)	0.001	0.002	0.789 (0.452-1.377)	0.403	0.806	0.663 (0.511-0.860)	0.002	0.004	0.719 (0.583-0.887)	0.002	0.004
rs2670660	G	0.716 (0.549-0.934)	0.014	0.028	0.909 (0.439-1.881)	0.796	—	0.711 (0.541-0.935)	0.015	0.030	0.769 (0.610-0.970)	0.026	0.052

SNP: single-nucleotide polymorphisms; OR: odds ratio; 95% CI: 95% confidence intervals; : value after correction for multiple comparisons; dominant model is Mm+mm vs. MM; recessive model is mm vs. MM+Mm; overdominant model is Mm vs. MM+mm; additive model is MM vs. Mm vs. mm; MM is homozygous dominant; Mm is heterozygous; mm is homozygous recessive.