TY - JOUR A2 - Reverter, Jordi Lluis AU - Chung, Yoo-Ri AU - Kim, Young Ho AU - Ha, Seong Jung AU - Byeon, Hye-Eun AU - Cho, Chung-Hyun AU - Kim, Jeong Hun AU - Lee, Kihwang PY - 2019 DA - 2019/12/20 TI - Role of Inflammation in Classification of Diabetic Macular Edema by Optical Coherence Tomography SP - 8164250 VL - 2019 AB - Diabetic macular edema (DME) is the abnormal accumulation of fluid in the subretinal or intraretinal spaces in the macula in patients with diabetic retinopathy and leads to severely impaired central vision. Technical developments in retinal imaging systems have led to many advances in the study of DME. In particular, optical coherence tomography (OCT) can provide longitudinal and microstructural analysis of the macula. A comprehensive review was provided regarding the role of inflammation using OCT-based classification of DME and current and ongoing therapeutic approaches. In this review, we first describe the pathogenesis of DME, then discuss the classification of DME based on OCT findings and the association of different types of DME with inflammation, and finally describe current and ongoing therapeutic approaches using OCT-based classification of DME. Inflammation has an important role in the pathogenesis of DME, but its role appears to differ among the DME phenotypes, as determined by OCT. It is important to determine how the different DME subtypes respond to intravitreal injections of steroids, antivascular endothelial growth factor agents, and other drugs to improve prognosis and responsiveness to treatment. SN - 2314-6745 UR - https://doi.org/10.1155/2019/8164250 DO - 10.1155/2019/8164250 JF - Journal of Diabetes Research PB - Hindawi KW - ER -